Dichlorvos (DDVP) Risk Characterization Document - California ...

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Table 1. The acute toxicity of DDVP (Continued). Species Sex Results References a DESMETHYL DDVP Intraperitoneal LD 50 Mouse F 1500 mg/kg 3 DICHLOROACETALDEHYDE Intraperitoneal LD 50 Mouse F 440 mg/kg 3 DICHLOROETHANOL Intraperitoneal LD 50 Mouse F 890 mg/kg 3 DICHLOROACETIC ACID Intraperitoneal LD 50 Mouse F 250 mg/kg 3 a/ 3. Casida et al., 1962 23
Table 2. Selected no-observed-effect levels (NOELs) and lowest-observed-effect levels (LOELs) of DDVP for sublethal acute effects from acute studies. Plasma ChE a RBC ChE a Brain ChE a Other Effects Species Route Duration a NOEL LOEL % C NOEL LOEL % C NOEL LOEL % C NOEL LOEL Effects Ref. b (mg/kg-day) (mg/kg-day) (mg/kg-day) (mg/kg-day) Rat c gavage 1 dose >30 no effect - 30 d 47-91% - - 9 13 irritability, salivation, 1 diarrhea, tremors Rat gavage 1 dose - - - - - - 0.5 1.0 gait alteration 2 Rat gavage 1 dose - - - - - - 0.5 35 gait alteration, pupillary 3 constriction, tremors, and others Rat e gavage d6-15 - - - - - - 3 21 tremors after each dosing 4* gestation Chicken f oral 1 dose - - - - - - - 16.5 d nerve fiber degeneration, 5 axonal swelling Rat inhal 4 h - - - - - - 8 14 lethargy, pupillary constriction 6 Rabbit e inhal d1-28 - - - - - - 0.65 1.0 death in 2-3 days 7 Human inhal 18h/dx5d >0.07 no effect >0.07 no effect - - >0.07 no effect 8 new born Human inhal 24h/dx1-5d 9 men without liver disease 0.02 0.031 28-65% >0.031 no effect - - >0.031 no effect men with liver disease - 0.006 35-67% >0.006 no effect - - >0.006 no effect women (labor and postpartum) >0.026 no effect >0.026 no effect - - >0.026 no effect sick children 0.014 0.02 55-92% >0.02 no effect - - >0.02 no effect a/ b/ c/ d/ e/ f/ Abbreviations: ChE=cholinesterase, RBC=erythrocyte, inhal=inhalation, h=hours, d=days, % C=% of control values at the LOEL, -=data not available. * after the reference number indicates the study was acceptable according to FIFRA guidelines. References: 1. Tracy et al., 1960; 2. Lamb, 1992; 3. Lamb, 1993a; 4. Tyl et al., 1991a; 5. Beavers et al., 1988; 6. Blair et al., 1975; 7. Thorpe et al., 1971b; 8. Cavagna et al., 1970; and 9. Cavagna et al., 1969. The study is described in III.C. SUBCHRONIC TOXICITY. The only concentration tested, not necessarily the LOEL. The study is described in III.G. DEVELOPMENTAL TOXICITY. The study is described in III.H. NEUROTOXICITY. 24
Page 1 and 2: DICHLORVOS (DDVP) RISK CHARACTERIZA
Page 3 and 4: transmitter of signals from the ner
Page 5 and 6: Contributors and Acknowledgments Pr
Page 7 and 8: List of Tables Pages 1. The acute t
Page 9 and 10: hematocrit) in rats. From studies w
Page 11 and 12: II. INTRODUCTION The human health r
Page 13 and 14: food service facilities); hand-held
Page 15 and 16: G. ENVIRONMENTAL FATE Summary: DDVP
Page 17 and 18: III. TOXICOLOGY PROFILE Pharmacokin
Page 19 and 20: Inhalation - Rat Carworth Farm stra
Page 21 and 22: DIMETHYL PHOSPHATE Oral - Rat Rats
Page 23 and 24: B. ACUTE TOXICITY Summary: The acut
Page 25 and 26: Oral - Human One hundred and eight
Page 27 and 28: Table 1. The acute toxicity of DDVP
Page 29: Table 1. The acute toxicity of DDVP
Page 33 and 34: dose-related manner. At a dosage of
Page 35 and 36: pretreatment levels, respectively.
Page 37 and 38: Table 3. Selected no-observed-effec
Page 39 and 40: Gavage - Rat In a study conducted b
Page 41 and 42: ate (Appendix D) and the assumption
Page 43 and 44: Gavage - Mouse In a study conducted
Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
Page 47 and 48: Table 9. The no-observed-effect lev
Page 49 and 50: Mice exposed to DDVP by inhalation
Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
Page 53 and 54: Table 11. The dosages and the inhib
Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
Page 57 and 58: levels not verified, too few pregna
Page 59 and 60: H. NEUROTOXICITY Summary: Possible
Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
Page 63 and 64: Acute Toxicity Inhalation The criti
Page 65 and 66: ates were not statistically signifi
Page 67 and 68: In mice, there were dose-related in
Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
Page 71 and 72: The U.S. Department of Agriculture
Page 73 and 74: Acute Exposure Estimates of potenti
Page 75 and 76: Table 19. Commodity contribution of
Page 77 and 78: C. RISK CHARACTERIZATION The potent
Page 79 and 80: Table 23. The margins of safety for
Page 81 and 82:
Table 25. The margins of safety of
Page 83 and 84:
label between treatment and the ava
Page 85 and 86:
VI. TOLERANCE ASSESSMENT A. BACKGRO
Page 87 and 88:
VII. CONCLUSIONS The toxicological
Page 89 and 90:
Bomhard, E., and M. Rinke, 1994. Fr
Page 91 and 92:
DPR, 1992. Sampling for pesticide r
Page 93 and 94:
Horn, K.-H., B. Teichmann, and T. S
Page 95 and 96:
NTP (National Toxicology Program),
Page 97 and 98:
TAS, 1992a. Exposure 4 . Detailed
Page 99 and 100:
Warf Institute Inc., 1977c. Acute e
Page 101 and 102:
APPENDIX A U.S. ENVIRONMENTAL PROTE
Page 103 and 104:
APPENDIX B Department of Pesticide
Page 105 and 106:
TABLE 2: Percent DDVP Dermal Absorp
Page 107 and 108:
RESIDENT EXPOSURES Environmental mo
Page 109 and 110:
post-treatment, respectively. Glove
Page 111 and 112:
Ross, J.H., H.R. Fong, , T. Thongsi
Page 113 and 114:
APPENDIX C NALED TOXICOLOGY OF NALE
Page 115 and 116:
APPENDIX D CALCULATION EQUATIONS 1.
Page 117 and 118:
APPENDIX E ONCOGENICITY POTENCY CAL
Page 119:
APPENDIX E (continued) ONCOGENICITY
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