Dichlorvos (DDVP) Risk Characterization Document - California ...

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Table 1. The acute toxicity of DDVP (Continued). Species Sex Results References a PRESSURIZED LIQUID (0.186-6.51%) Oral LD 50 Rat M/F 2.5-> 50 mg/kg 9, 10 Dermal LD 50 Rabbit M/F > 200 mg/kg 10 Inhalation LC 50 Rat M/F > 5 mg/L (4 hrs) 10 Rat na b > 200 mg/L (1 hr) 11 Ocular Irritation Rabbit na non-irritant 10, 12 Dermal Irritation Rabbit na severe/moderate 10, 13 IMPREGNATED RESIN (20%, strips) Oral LD 50 Rat na 400-1,200 mg/kg 14 Dermal LD 50 Rabbit na 24,000-50,000 mg/kg 14 IMPREGNATED RESIN (20%, controlled release aerosol) Oral LD 50 Rat M/F 180-593 mg/kg 15, 16 Dermal LD 50 Rabbit M/F > 2000 mg/kg 17 Ocular Irritation Rabbit M/F mild 18 Dermal Irritation Rabbit na mild 19 a/ b/ 9. Warf Institute Inc., 1977a; 10. Pet Chemicals Inc., 1983; 11. Warf Institute Inc., 1977b; 12. Warf Institute Inc., 1977c; 13. Warf Institute Inc., 1977d; 14. Shell Chemical Co., 1965; 15. Pharmakon Research International, 1987; 16. Springborn Institute, 1987; 17. Pharmakon Research International, 1985; 18. Pharmakon Research International, 1989; 19. Pharmakon Research International, 1984. na=not available 21
Table 1. The acute toxicity of DDVP (Continued). Species Sex Results References a FOGGER (DDVP 0.47%, Propoxur 1.0%, Methoprene 0.15%) Oral LD 50 Rat M/F 2.16 g/kg 20 Dermal LD 50 Rabbit na b 7.4 g/kg 21 Inhalation LC 50 Rat na > 5.83 mg/L 22 Ocular irritation Rabbit na mild 23 Dermal irritation Rabbit na mild 24 FOGGER (DDVP 0.5%, Pyrethrum 0.25%) Oral LD 50 Rat M/F > 5 g/kg 25 Dermal LD 50 Rabbit M/F > 2 g/kg 25 Inhalation LC 50 Rat M/F > 20.3 mg/L 25 Ocular irritation Rabbit na mild 25 Dermal irritation Rabbit na mild 25 a/ b/ 20. Elars Bioresearch Lab., 1980a; 21. Elars Bioresearch Lab., 1980b; 22. Hazleton Lab., 1980; 23. Elars Bioresearch Lab., 1980c; 24. Elars Bioresearch Lab., 1980d; 25. S.C. Johnson & Sons, 1980. na=not available 22
Page 1 and 2: DICHLORVOS (DDVP) RISK CHARACTERIZA
Page 3 and 4: transmitter of signals from the ner
Page 5 and 6: Contributors and Acknowledgments Pr
Page 7 and 8: List of Tables Pages 1. The acute t
Page 9 and 10: hematocrit) in rats. From studies w
Page 11 and 12: II. INTRODUCTION The human health r
Page 13 and 14: food service facilities); hand-held
Page 15 and 16: G. ENVIRONMENTAL FATE Summary: DDVP
Page 17 and 18: III. TOXICOLOGY PROFILE Pharmacokin
Page 19 and 20: Inhalation - Rat Carworth Farm stra
Page 21 and 22: DIMETHYL PHOSPHATE Oral - Rat Rats
Page 23 and 24: B. ACUTE TOXICITY Summary: The acut
Page 25 and 26: Oral - Human One hundred and eight
Page 27: Table 1. The acute toxicity of DDVP
Page 31 and 32: Table 2. Selected no-observed-effec
Page 33 and 34: dose-related manner. At a dosage of
Page 35 and 36: pretreatment levels, respectively.
Page 37 and 38: Table 3. Selected no-observed-effec
Page 39 and 40: Gavage - Rat In a study conducted b
Page 41 and 42: ate (Appendix D) and the assumption
Page 43 and 44: Gavage - Mouse In a study conducted
Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
Page 47 and 48: Table 9. The no-observed-effect lev
Page 49 and 50: Mice exposed to DDVP by inhalation
Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
Page 53 and 54: Table 11. The dosages and the inhib
Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
Page 57 and 58: levels not verified, too few pregna
Page 59 and 60: H. NEUROTOXICITY Summary: Possible
Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
Page 63 and 64: Acute Toxicity Inhalation The criti
Page 65 and 66: ates were not statistically signifi
Page 67 and 68: In mice, there were dose-related in
Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
Page 71 and 72: The U.S. Department of Agriculture
Page 73 and 74: Acute Exposure Estimates of potenti
Page 75 and 76: Table 19. Commodity contribution of
Page 77 and 78: C. RISK CHARACTERIZATION The potent
Page 79 and 80:
Table 23. The margins of safety for
Page 81 and 82:
Table 25. The margins of safety of
Page 83 and 84:
label between treatment and the ava
Page 85 and 86:
VI. TOLERANCE ASSESSMENT A. BACKGRO
Page 87 and 88:
VII. CONCLUSIONS The toxicological
Page 89 and 90:
Bomhard, E., and M. Rinke, 1994. Fr
Page 91 and 92:
DPR, 1992. Sampling for pesticide r
Page 93 and 94:
Horn, K.-H., B. Teichmann, and T. S
Page 95 and 96:
NTP (National Toxicology Program),
Page 97 and 98:
TAS, 1992a. Exposure 4 . Detailed
Page 99 and 100:
Warf Institute Inc., 1977c. Acute e
Page 101 and 102:
APPENDIX A U.S. ENVIRONMENTAL PROTE
Page 103 and 104:
APPENDIX B Department of Pesticide
Page 105 and 106:
TABLE 2: Percent DDVP Dermal Absorp
Page 107 and 108:
RESIDENT EXPOSURES Environmental mo
Page 109 and 110:
post-treatment, respectively. Glove
Page 111 and 112:
Ross, J.H., H.R. Fong, , T. Thongsi
Page 113 and 114:
APPENDIX C NALED TOXICOLOGY OF NALE
Page 115 and 116:
APPENDIX D CALCULATION EQUATIONS 1.
Page 117 and 118:
APPENDIX E ONCOGENICITY POTENCY CAL
Page 119:
APPENDIX E (continued) ONCOGENICITY
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