Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
to gestation day 28 (Thorpe et al., 1971b). Severe toxicity and mortality were observed after the 6th day of exposure in the 6.25 ug/L (3.25 mg/kg-day) group. Cholinergic signs observed included anorexia, lethargy, muscular tremors, mucous nasal discharges, and diarrhea. Severely affected rabbits were prone with heads turned to one side. Sixteen of 20 does died or were killed because of intoxication. In the second experiment by Thorpe et al. (1971b), Dutch rabbits (20/group) were exposed to DDVP (0 to 4 ug/L, equivalent to 0 to 2.0 mg/kg-day) by inhalation. One doe in the 2 ug/L (1.0 mg/kg-day) group died after 2-3 days of exposure. Six does of the 4 ug/L group died or were killed because severe cholinergic signs. 19
Table 1. The acute toxicity of DDVP. Species Sex Results References a TECHNICAL GRADE Oral LD 50 Rat M/F 56-80 mg/kg 1 Mouse na b 184 mg/kg 2 Dog na 100-316 mg/kg 2 Intraperitoneal LD 50 Rat M/F 6 mg/kg 2 Mouse F 28 mg/kg 3 Dermal LD 50 Rat M/F 75-107 mg/kg 1 Inhalation LC 50 Rat M 14.8 ug/L (4 hrs) 2 Mouse M 13.2 ug/L (4 hrs) 2 Ocular Irritation Rabbit na mild 4 Dermal Irritation Rabbit na mild 4 LIQUID CONCENTRATE (1.0-23.25%) Oral LD 50 Rat M/F 3200-10,000 mg/kg 5 Dermal LD 50 Rabbit M 1800 mg/kg 6 Rabbit na < 200 mg/kg 7 Ocular Irritation Rabbit na mild 8 Dermal Irritation Rabbit na moderate 9 a/ b/ 1. Gaines, 1960; 2. Denka Chemie BV, 1982; 3. Casida et al., 1962; 4. USEPA, 1987; 5. The Hine Lab., 1973a; 6. The Hine Lab., 1973b; 7. Unilab Research Inc., 1981; 8. Product Safety Lab., 1982a; 9. Product Safety Lab., 1982b. na=not available 20
- Page 1 and 2: DICHLORVOS (DDVP) RISK CHARACTERIZA
- Page 3 and 4: transmitter of signals from the ner
- Page 5 and 6: Contributors and Acknowledgments Pr
- Page 7 and 8: List of Tables Pages 1. The acute t
- Page 9 and 10: hematocrit) in rats. From studies w
- Page 11 and 12: II. INTRODUCTION The human health r
- Page 13 and 14: food service facilities); hand-held
- Page 15 and 16: G. ENVIRONMENTAL FATE Summary: DDVP
- Page 17 and 18: III. TOXICOLOGY PROFILE Pharmacokin
- Page 19 and 20: Inhalation - Rat Carworth Farm stra
- Page 21 and 22: DIMETHYL PHOSPHATE Oral - Rat Rats
- Page 23 and 24: B. ACUTE TOXICITY Summary: The acut
- Page 25: Oral - Human One hundred and eight
- Page 29 and 30: Table 1. The acute toxicity of DDVP
- Page 31 and 32: Table 2. Selected no-observed-effec
- Page 33 and 34: dose-related manner. At a dosage of
- Page 35 and 36: pretreatment levels, respectively.
- Page 37 and 38: Table 3. Selected no-observed-effec
- Page 39 and 40: Gavage - Rat In a study conducted b
- Page 41 and 42: ate (Appendix D) and the assumption
- Page 43 and 44: Gavage - Mouse In a study conducted
- Page 45 and 46: Capsules - Dog DDVP (97.3-99.5% pur
- Page 47 and 48: Table 9. The no-observed-effect lev
- Page 49 and 50: Mice exposed to DDVP by inhalation
- Page 51 and 52: F. REPRODUCTIVE TOXICITY Summary: E
- Page 53 and 54: Table 11. The dosages and the inhib
- Page 55 and 56: G. DEVELOPMENTAL TOXICITY Summary:
- Page 57 and 58: levels not verified, too few pregna
- Page 59 and 60: H. NEUROTOXICITY Summary: Possible
- Page 61 and 62: IV. RISK ASSESSMENT A. HAZARD IDENT
- Page 63 and 64: Acute Toxicity Inhalation The criti
- Page 65 and 66: ates were not statistically signifi
- Page 67 and 68: In mice, there were dose-related in
- Page 69 and 70: B. EXPOSURE ASSESSMENT The exposure
- Page 71 and 72: The U.S. Department of Agriculture
- Page 73 and 74: Acute Exposure Estimates of potenti
- Page 75 and 76: Table 19. Commodity contribution of
to gestation day 28 (Thorpe et al., 1971b). Severe toxicity and mortality were observed after the 6th<br />
day of exposure in the 6.25 ug/L (3.25 mg/kg-day) group. Cholinergic signs observed included<br />
anorexia, lethargy, muscular tremors, mucous nasal discharges, and diarrhea. Severely affected<br />
rabbits were prone with heads turned to one side. Sixteen of 20 does died or were killed because of<br />
intoxication.<br />
In the second experiment by Thorpe et al. (1971b), Dutch rabbits (20/group) were exposed to <strong>DDVP</strong><br />
(0 to 4 ug/L, equivalent to 0 to 2.0 mg/kg-day) by inhalation. One doe in the 2 ug/L (1.0 mg/kg-day)<br />
group died after 2-3 days of exposure. Six does of the 4 ug/L group died or were killed because<br />
severe cholinergic signs.<br />
19
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