Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ...
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APPENDIX E<br />
ONCOGENICITY POTENCY CALCULATIONS<br />
GLOBAL 86 (MAY 1986)<br />
BY RICHARD B. HOWE AND CYNTHIA VAN LANDINGHAM<br />
CLEMENT ASSOCIATES, 1201 GAINES STREET, RUSTON, LA 71270 (318) 255-4800<br />
Pancreatic adenoma in male rats dosed <strong>DDVP</strong> by gavage for 2 years<br />
POLYNOMIAL DEGREE SELECTED BY PROGRAM, (POLY-DEGREE=0)<br />
MONTE CARLO TEST USED IN SELECTION<br />
#RESPONSES<br />
#RESPONSES<br />
GROUP DOSE OBSERVED/#ANIMALS PREDICTED<br />
1 0.00000 16/ 50 16.31<br />
2 2.90000 25/ 49 24.06<br />
3 5.70000 30/ 50 30.59<br />
CHI-SQUARE GOODNESS OF FIT STATISTIC IS .11014<br />
P-VALUE FOR THE MONTE CARLO TEST IS .4650000000<br />
FORM OF PROBABILITY FUNCTION:<br />
P(DOSE) = 1 - exp( -Q0 - Q1 * D - Q2 * D^2 )<br />
MAXIMUM LIKELIHOOD ESTIMATES OF DOSE COEFFICIENTS<br />
Q( 0) = .394703118704<br />
Q( 1) = 9.680185659774E-02<br />
Q( 2) = .000000000000<br />
MAXIMUM VALUE OF THE LOG-LIKELIHOOD IS -99.0030875953<br />
CALCULATIONS ARE BASED UPON EXTRA RISK<br />
GLOBAL 86 LOWER CONFIDENCE LIMITS ON DOSE FOR FIXED RISK<br />
*********************************************************<br />
LOWER BOUND CONFIDENCE COEFFICIENTS FOR<br />
RISK MLE DOSE ON DOSE LIMIT SIZE CONFIDENCE LIMIT<br />
---- -------- ----------- ---------- ----------------<br />
1.00000E-06 1.03304E-05 6.49111E-06 95.0% Q( 0) = .31574<br />
Q( 1) = .15406<br />
Q( 2) = .00000