Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ... Dichlorvos (DDVP) Risk Characterization Document - California ...
APPENDIX D (continued) CALCULATION EQUATIONS 3. Margin of Safety: Margin of Safety NOEL exposure level 4. Human equivalency in potency from animal data to human: The equivalency in potency from animal to human is calculated based on the body weight to the 3/4 power (Davidson et al., 1986; Travis and White, 1988). Dose A Dose H × BW H BW 3 / 4 A BW A BW 3 / 4 H Dose H Dose A x ( BW A BW H ) 1 / 4 Therefore, q 1 H q 1 A ×(BW H BW A ) 1 / 4 BW=body weight, A=animal, and H=human. Body weights used were: 70 kg for human, 0.50 kg for rat, and 0.037 kg for mouse.
APPENDIX E ONCOGENICITY POTENCY CALCULATIONS GLOBAL 86 (MAY 1986) BY RICHARD B. HOWE AND CYNTHIA VAN LANDINGHAM CLEMENT ASSOCIATES, 1201 GAINES STREET, RUSTON, LA 71270 (318) 255-4800 Pancreatic adenoma in male rats dosed DDVP by gavage for 2 years POLYNOMIAL DEGREE SELECTED BY PROGRAM, (POLY-DEGREE=0) MONTE CARLO TEST USED IN SELECTION #RESPONSES #RESPONSES GROUP DOSE OBSERVED/#ANIMALS PREDICTED 1 0.00000 16/ 50 16.31 2 2.90000 25/ 49 24.06 3 5.70000 30/ 50 30.59 CHI-SQUARE GOODNESS OF FIT STATISTIC IS .11014 P-VALUE FOR THE MONTE CARLO TEST IS .4650000000 FORM OF PROBABILITY FUNCTION: P(DOSE) = 1 - exp( -Q0 - Q1 * D - Q2 * D^2 ) MAXIMUM LIKELIHOOD ESTIMATES OF DOSE COEFFICIENTS Q( 0) = .394703118704 Q( 1) = 9.680185659774E-02 Q( 2) = .000000000000 MAXIMUM VALUE OF THE LOG-LIKELIHOOD IS -99.0030875953 CALCULATIONS ARE BASED UPON EXTRA RISK GLOBAL 86 LOWER CONFIDENCE LIMITS ON DOSE FOR FIXED RISK ********************************************************* LOWER BOUND CONFIDENCE COEFFICIENTS FOR RISK MLE DOSE ON DOSE LIMIT SIZE CONFIDENCE LIMIT ---- -------- ----------- ---------- ---------------- 1.00000E-06 1.03304E-05 6.49111E-06 95.0% Q( 0) = .31574 Q( 1) = .15406 Q( 2) = .00000
- Page 65 and 66: ates were not statistically signifi
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- Page 77 and 78: C. RISK CHARACTERIZATION The potent
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- Page 85 and 86: VI. TOLERANCE ASSESSMENT A. BACKGRO
- Page 87 and 88: VII. CONCLUSIONS The toxicological
- Page 89 and 90: Bomhard, E., and M. Rinke, 1994. Fr
- Page 91 and 92: DPR, 1992. Sampling for pesticide r
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- Page 97 and 98: TAS, 1992a. Exposure 4 . Detailed
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- Page 113 and 114: APPENDIX C NALED TOXICOLOGY OF NALE
- Page 115: APPENDIX D CALCULATION EQUATIONS 1.
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APPENDIX D (continued)<br />
CALCULATION EQUATIONS<br />
3. Margin of Safety:<br />
Margin of Safety <br />
NOEL<br />
exposure level<br />
4. Human equivalency in potency from animal data to human:<br />
The equivalency in potency from animal to human is calculated based on the body weight to the 3/4<br />
power (Davidson et al., 1986; Travis and White, 1988).<br />
Dose A<br />
Dose H<br />
× BW H<br />
BW 3 / 4<br />
A<br />
BW A<br />
BW 3 / 4<br />
H<br />
Dose H<br />
Dose A<br />
x ( BW A<br />
BW H<br />
) 1 / 4<br />
Therefore,<br />
q 1 H q 1 A ×(BW H<br />
BW A<br />
) 1 / 4<br />
BW=body weight, A=animal, and H=human. Body weights used were: 70 kg for human, 0.50 kg for<br />
rat, and 0.037 kg for mouse.
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