Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ...
Dichlorvos (DDVP) Risk Characterization Document - California ...
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APPENDIX D<br />
CALCULATION EQUATIONS<br />
1. Dosage estimation for animals from an inhalation study (exposure level in ppm):<br />
mg/kgdaymg/m 3 ×respiration rate(m 3 hours exposed days exposed/week<br />
/kgday)× × ×AF<br />
24 hours<br />
7 days<br />
For this equation, 1 ug/L in air is equivalent to 1 mg/m 3 . The term for number of days exposed per<br />
week/7 days is used in the calculation only for studies when the animals were not dosed every day.<br />
The dosage was not corrected for absorption (absorption factor, AF). Only the dosages used in the<br />
calculation of MOS are corrected for 50% inhalation absorption rate.<br />
The default respiration rates used are: 0.46 m 3 /kg-day for children, 0.26 m 3 /kg-day for human adults,<br />
0.96 m 3 /kg-day for rats, 0.54 m 3 /kg-day for rabbits, and 1.80 m 3 /kg-day for mice (Zielhuis and van der<br />
Kreek, 1979).<br />
For example:<br />
Using the NOEL of 1.25 ug/L from Thorpe et al. (1971b) where rabbits were exposed<br />
to <strong>DDVP</strong> daily,<br />
1.25 mg<br />
× 0.54 m 3<br />
m 3 kgday<br />
×<br />
23 hours<br />
24 hours<br />
0.65 mg/kgday<br />
2. Dosage estimation for animals in a dietary study (exposure level expressed as ppm in the diet):<br />
ug/kgday ppm (ug/g) xFR(g/day) x<br />
1<br />
body weight (kg)<br />
x<br />
days exposed/week<br />
7days<br />
The food consumption rate (FR) is derived either from the reports or the standard default is used. The<br />
standard default is based on body weight, 15% for mouse, 5% for rat, and 3% for rabbit.