TOXICOLOGICAL PROFILE FOR BARIUM AND COMPOUNDS ...

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ii DISCLAIMER The use of company or product name(s) is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry.
iii <strong>FOR</strong>EWORD The Superfund Amendments and Reauthorization Act of 1986 (Public Law 99-499) extended and amended the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA or Superfund). This public law (also known as SARA) directed the Agency for Toxic Substances and Disease Registry (ATSDR) to prepare toxicological profiles for hazardous substances which are most commonly found at facilities on the CERCLA National Priorities List and which pose the most significant potential threat to human health, as determined by ATSDR and the Environmental Protection Agency (EPA). The list of the 200 most significant hazardous substances was published in the Federal Register on April 17, 1987 and on October 20, 1988. Section 110 (3) of SARA directs the Administrator of ATSDR to prepare a toxicological profile for each substance on the list. Each profile must include the following content: (A) An examination, summary, and interpretation of available toxicological information and epidemiological evaluations on the hazardous substance in order to ascertain the levels of significant human exposure for the substance and the associated acute, subacute, and chronic health effects, (B) A determination of whether adequate information on the health effects of each substance is available or in the process of development to determine levels of exposure which present a significant risk to human health of acute, subacute, or chronic health effects, and (C) Where appropriate, an identification of toxicological testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. This toxicological profile is prepared in accordance with guidelines developed by ATSDR and EPA. The original guidelines were published in the Federal Register on April 17, 1987. Each profile will be revised and republished as necessary, but no less often than every three years, as required by SARA. The ATSDR toxicological profile is intended to characterize succinctly the toxicological and health effects information for the hazardous substance being described. Each profile identifies and reviews the key literature that describes a hazardous substance's toxicological properties. Other literature is presented but described in less detail than the key studies. The profile is not intended to be an exhaustive document; however, more comprehensive sources of specialty information are referenced.
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Page 14 and 15: 2 1. PUBLIC HEALTH STATEMENT chlori
Page 16 and 17: 4 1. PUBLIC HEALTH STATEMENT irrita
Page 19 and 20: 7 2. HEALTH EFFECTS 2.1 INTRODUCTIO
Page 21 and 22: 9 2. HEALTH EFFECTS from any of the
Page 23 and 24: 11 2. HEALTH EFFECTS 2.2.1.5 Develo
Page 25: 13 2. HEALTH EFFECTS Mortality has
Page 34 and 35: 22 2. HEALTH EFFECTS either 0.071,
Page 36 and 37: 24 2. HEALTH EFFECTS plasma fibrino
Page 38 and 39: 26 2. HEALTH EFFECTS rats and mice
Page 40 and 41: 28 2. HEALTH EFFECTS barium/kg/day
Page 42 and 43: 30 2. HEALTH EFFECTS purulent disch
Page 44 and 45: 32 2. HEALTH EFFECTS Experiments in
Page 46 and 47: 34 2. HEALTH EFFECTS Animal studies
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40 2. HEALTH EFFECTS system were re
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42 2. HEALTH EFFECTS microscopic le
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44 2. HEALTH EFFECTS designed to te
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46 2. HEALTH EFFECTS either appeara
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48 2. HEALTH EFFECTS Barbiturates h
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51 2. HEALTH EFFECTS Singh 1970; Di
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53 2. HEALTH EFFECTS Reduced lifesp
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55 2. HEALTH EFFECTS Developmental
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57 2. HEALTH EFFECTS of barium, wel
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59 3. CHEMICAL AND PHYSICAL INFORMA
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71 4. PRODUCTION, IMPORT, USE, AND
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73 5. POTENTIAL FOR HUMAN EXPOSURE
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93 6. ANALYTICAL METHODS 6.2 ENVIRO
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97 6. ANALYTICAL METHODS However, i
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105 8. REFERENCES ACGIH. 1982. TLVs
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107 8. REFERENCES *Boothe PN. James
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109 8. REFERENCES Clary JJ, Tardiff
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111 8. REFERENCES Douglas WW, Rubin
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113 8. REFERENCES *EPA. 1984. Healt
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115 8. REFERENCES *FSTRhC. 1988. Fe
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117 8. REFERENCES *Hem JD. 1959. St
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119 8. REFERENCES Kolpakov W. 1971.
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121 8. REFERENCES *McCauley PT, Dou
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123 8. REFERENCES NIOSH. 1987a. NIO
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125 8. REFERENCES *Pierce FD, Brown
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127 8. REFERENCES *Sax NI, Lewis RJ
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129 8. REFERENCES Simmonds RJ, Jame
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131 8. REFERENCES Syed IB, Hosain F
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133 8. REFERENCES Weiss G, ed. 1986
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136 9. GLOSSARY Immediately Dangero
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138 9. GLOSSARY Short-Term Exposure
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A-2 APPENDIX A three LSE tables and
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A-4 APPENDIX A (18). Estimated Uppe
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A-8 APPENDIX A MRL users should be
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