Tarek Aboul-Fadl, Ph.D. Curriculum Vitae - Assiut University

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 2 of 26
Name : Tarek Aboul-Fadl Mohamed Hassan.
Birth date / Place : August 31, 1961, Qena-Egypt.
Marital Status : Married, 3 children.
Nationality : Egyptian.
Education :
1. Ph.D. in Pharm. Sciences, (Pharm. Med. Chem.) on "Synthesis and
Investigation of N 4 -Substituted Cytarabine (Ara-C) Derivatives as
Prodrugs", January 1994, Assiut University - Egypt and Josai University,
Saitama, Japan under the channel system and joint supervision scheme.
2. M. Sc. in Pharm. Sciences, (Pharm. Chem.), on "Synthesis of
Chelating Pyrazole Derivatives with potential Biological Activity",
November 1989, Assiut University.
3. B. Sc. in Pharmaceutical Sciences with grade " V. good with degree of
honor ", June 1984, Assiut University.
Current Position: Professor
Experience Record :
1. Professor of Pharmaceutical Chemistry at the Faculty of Pharmacy- Assiut
University, Egypt. July 25, 2004 to date.
2. Professor of Pharmaceutical Chemistry at the College of Pharmacy- King
Saud University, Saudi Arabia. August 2005 – June 2012.
3. Senior Scientist at Department of Medicinal Chemistry, University of
Utah, USA, February 2004- August 2005.
4. Postdoctoral fellow, Department of Medicinal Chemistry, University of
Utah, USA, May 2001- November 2002
5. Postdoctoral fellow, Institute of Pharmacy and Food Chemistry, University
of Erlangen-Nürnberg, Germany, September-December 1999.
6. Associate Professor of Pharmaceutical Chemistry at the Faculty of
Pharmacy- Assiut University, Egypt. May 30,1999 - July 24,2004.

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Curriculum Vitae, Page 3 of 26
7. Postdoctoral fellow, Institute of Pharmaceutical Chemistry, University of
Vienna, Austria, December 1997- August 1998.
8. Lecturer of Pharmaceutical Chemistry at the Faculty of Pharmacy- Assiut
University, Egypt. Feb. 20,1994 - May 29,1999.
9. Research fellow, Faculty of Pharm. Sciences, Josai University, Sakado,
Saitama, Japan, May 1991- August 1993.
10. Associate lecturer, Department of Pharmaceutical Chemistry, Assiut
University-Egypt, Dec. 4,1989 - Feb. 19,1994.
11. Demonstrator, Department of Pharmaceutical Chemistry, Assiut
University-Egypt, Oct.14,1984 - Dec. 3,1989.
Teaching Experiences:
1. Teaching Pharm., Med. and Org. Chem. courses for under- and graduate
students of Assiut University – Egypt (1994-Now).
2. Teaching Summer course of Drug Design (PHC 433) for undergraduate
students of Miser International University (MIU) – Egypt (2012).
3. Teaching Pharm., Med. and Org. Chem. courses for under- and graduate
students of King Saud University – Saudi Arabia (2005-2012)
Courses Taught at King Saud University :
A. Courses of Undergraduate Students
1- Pharmaceutical Organic Chemistry (PCH 251)
2- Medicinal Chemistry I (PCH 271)
3- Medicinal Chemistry II (PCH 371)
4- Spectrometric Identification Of Pharmaceutical Compounds (PCH 472)
5- Pharmaceutical Organic Chemistry (PCH 211)
6- Medicinal Chemistry I (PCH 222)
7- Drug Discovery & Development (PCH 311)
8- Medicinal Chemistry II (PCH 313)
B. Courses of Graduate Students
1. Biopharmaceutical Reactions Mechanisms (PCH 511)
2. Modern Synthetic Reactions (PCH 512)
3. Stereochemical Aspects in Medicinal Chemistry (PCH 670)

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 4 of 26
4. Structural Elucidation Techniques in Medicinal Chemistry (PCH 671)
5. Mechanistic And Catalytic Aspects In Medicinal Chemistry (PCH 674)
4. Teaching Med. Chem. courses for undergraduate students of Tanta
University – Egypt (1999-2000).
5. Teaching Pharm. Med. Chem. courses for under- and graduate students of
Assiut, Al-Azahar University (Assiut Branch) – Egypt (1996-1997).
6. Teaching Organic Chem. courses for graduate students of Assiut and Al-
Azahar (Assiut Branch) Universities – Egypt (1995-2001).
7. Teaching Lab. safety and waste disposal courses for graduate students of
Assiut and Al-Azahar (Assiut Branch) Universities – Egypt (1995-2001).
8. Tutor of undergraduate courses of Pharm. Med. and Organic Chem.
(main), and Analytical Pharm. Chem. (Secondary) – Egypt (1984-
1994).
Fellowships and Awards:
1. Research Fellowships from the Department of Medicinal Chemistry,
University of Utah, USA, February 2004- August 2005.
2. Research Fellowships from the Department of Medicinal Chemistry,
University of Utah, USA, May 2001- November 2002.
3. Postdoctoral Fellowships from German Academic Exchange (DAD),
September-December 1999.
4. Postdoctoral Fellowships from Institute of Pharmaceutical Chemistry,
University of Vienna, Austria, December 1997- August 1998.
5. Ph. D. grant from the Egyptian Ministry of High Education according to
channel system and joint supervision scheme at Josai University, Sakado,
Saitama, Japan, May 1991- August 1993.
Research Interests:
1. Prodrugs and chemical delivery systems.
2. Synthesis of organic compounds with potential antituburcular,
antimicrobial and antifungal activities

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 5 of 26
3. Synthesis of organoselenium derivatives with potential cancer preventive
activity.
4. Peptide nucleic acids and Oligonucleotids as antiviral agents.
5. Design, Synthesis and Evaluation of Small Combinatorial Library with Potential
Biological Activity
Supervision of Theses
A) Ph.D. Thesis:
1. Synthesis and SAR of Paeoniflorin and Paeonimetabolin-I Derivatives of
Potential Anticonvulsant and Muscle relaxant activities. (Approved)
2. Estimation of histamine in meat products as indicator for their
deterioration. (Approved)
3. Design, Synthesis, Characterization And Pharmacological Evaluation Of
Amide Prodrugs Of Some Non-Steroidal Anti-Inflammatory Drugs.
(Approved)
4. Synthesis and Evaluation of Amide Prodrugs of Some NSAIDs and Amino
Acid Derivatives with Potential Colorectal Cancer Chemopreventive
Activities
B) M. Sc. Thesis:
1. 1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New carriers for
Specific Delivery of Drugs to the Brain. (Approved)
2. Design, Synthesis and Antitubercular Evaluation of Small Schiff Base
Combinatorial Library. (Approved)
3. Synthesis of Some Schiff’s Bases of Indolin-2,3-dione and Quinolone
Carboxylic Acid Derivatives With Potential Antitubercular Activity.
(Approved)
Membership of Societies and Committees:
1. The Stop TB Partnership Working Group on New TB Drugs (WGND).
Feb. 2010. http://www.newtbdrugs.org/members.php?mode=alpha

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Curriculum Vitae, Page 6 of 26
2. American Chemical Society, Jan. 2002 to date.
3. Egyptian Society of Pharmacists, May 1994 to date.
4. Assiut University Staff members club, February 1994 to date.
5. Assiut University club, 1996 to date.
6. Egyptian Syndicate of Pharmacists, July 1984 to date.
Academic Administrative Activities at King Saud University:
1. Member of Pharmaceutical Chemistry Department Council, August 2005
to date.
2. Member of Pharmaceutical Chemistry Department Committee for the
Academic Affairs , 2005 to date.
3. Member of Pharmaceutical Chemistry Department Committee Responsible
for Conducting the Comprehensive Examination, both Written and Oral,
for the Ph. D. Students, 2006 to date.
4. Secretary Rite of Pharmaceutical Chemistry Department Council, 2007-
2009.
5. Member of Standing Committee of the University Scientific Council for
Recruiting, July 2008.
Conferences:
1. 243rd American Chemical Society meeting, San Diego, California -USA,
March 25-29, 2012.
2. 47 th International Conference on Medicinal Chemistry (RICT 2011), Lyon-
France, July 6 -8, 2011.
3. The 66 th Northwest Regional Meeting of The American Chemical Society
(NORM 2011), Portland, Oregon-USA, June 26 -29, 2011.
4. The CCG European User Group Meeting, Cambridge-UK, October 18 th to
19 th 2010.
5. The 46 th International Conference on Medicinal Chemistry (RICT 2010),
Reims-France, June 30 -July 2, 2010.

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 7 of 26
6. The 50 th Anniversary Meeting of the American Society of Pharmacognosy,
Honolulu, HI-USA, June 27-July 1, 2009.
7. 237 th American Chemical Society meeting, Salt Lake City, Utah-USA,
March 22-26, 2009.
8. 2 nd World Conference on Magic Bullets (Ehrlich II). Nürnberg, Germany,
October 3 - 5, 2008.
9. Fourth International Conference for Development and the Environment
(F.I.C.D.E.). Riyadh-Saudi Arabia, March 18-20, 2008.
10. The 7 th International Saudi Pharmaceutical Conference. Riyadh-Saudi
Arabia, March 19-21, 2007.
11. International Symposium on Food and Drug Regulation (present &
Outlook), Riyadh, Saudi Arabia, May 20-22, 2006.
12. The 9 th International Pharmaceutical Science Conference and Exposition.
Riyadh-Saudi Arabia, December 17-21 2005.
13. 229 th American Chemical Society meeting, San Diego, California-USA,
March 13-17, 2005.
14. The 22 nd Annual Meeting of the Mountain West Society of Toxicology
(MWSOT), Park City – Utah, USA. September 10, 2004.
15. Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-
USA, September 9, 2004.
16. The 2004 University of Utah College of Pharmacy Research Symposium,
Slat Lake City – Utah, USA, April 15, 2004.
17. The 1 st International Congress of Pharmaceutical and Drug Industries
Division, National Research Center, Cairo-Egypt, March 24-26,2003.
18. XXVIII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt,
December 17-19,2002.
19. 223 ed American Chemical Society meeting, Orlando, Florida-USA, April
6-11, 2002.

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Curriculum Vitae, Page 8 of 26
20. Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-
USA, August 30, 2001.
21. XXVII Conference of Egyptian Pharmaceutical Society, Cairo - Egypt,
January 2-4,2001.
22. Assiut University 2 nd International Pharmaceutical Sciences Conference,
Faculty of Pharmacy, Assiut-Egypt, March 8-9,2000.
23. XXVI Conference of Egyptian Pharmaceutical Society, Cairo - Egypt,
December 8-10,1998.
24. XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz, June
11-13, 1998.
25. XXV Conference of Egyptian Pharmaceutical Society, Cairo - Egypt,
December 24-26,1996.
26. Egyptian-German Conference on Medicinal Plants, Assiut - Egypt,
November 27, 1995.
27. Al-Azhar First International Conference on Recent Advances in
Pharmaceutical Technology and Biological Sciences, Cairo - Egypt,
December 19- 21, 1995.
28. World Congress of Pharmacy and Pharmaceutical Sciences 1993, (FIP'93),
Tokyo, Japan, September 5-10, 1993.
29. Symposium " Enhancement of Research Efficiency of Assistant Lecturer
and Demonstrators" Staff members Club of Assiut University, Assiut-
Egypt, February 23-28, 1991.
30. 3 rd IBN SINA Symposium on Heterocyclic Chemistry, Aswan - Egypt,
January 28-31, 1991.
Invited Lectures:
1. College of Pharmacy Research Center – King Saud University, Riyadh-Saudi
Arabia, December 6, 2006.

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Curriculum Vitae, Page 9 of 26
2. Life Science Research Center, Gifu University, Gifu-Japan, March 28-31,
2005. http://www.c-goudou.org/announce/an08csjj04.html
Training and Workshops:
1. Workshop on ChemSource, Portland-Oregon-USA, June 29 th 2011.
2. Workshop on Metro Hazardous Waste: Bottle Bombs and Detergent
Suicides, Portland-Oregon-USA, June 28 th 2011.
3. Workshop on Structure-Based Drug Design and Molecular Modelling, The
CCG European User Group Meeting, Cambridge-UK, October 20 th to 21 st
2010.
4. Training in chemical synthesis using microwave technology, CEM
Corporation, Matthews,Charlotte (NC) / USA, August 2-6 th 2010.
5. Drug Discovery Design & Planning Methods. echeminfo training
workshop. Medical Sciences Teaching Laboratory, Oxford University,
Oxford-UK, July 26-30 th ,2010.
6. Training in chemical synthesis using microwave technology and
Chromatographic purification using Isolera ® , Biotage-Upsala / Sweden,
July 19-22 ed 2010.
7. Introductory modeling and simulation techniques. German Association of
Pharmaceutical Scientists (DPhG). Nürnberg, Germany, October 3, 2008.
8. Overview of pharmacokinetics/pharmacodynamics software for optimal
design, & clinical trial simulation (DPhG). German Association of
Pharmaceutical Scientists. Nürnberg, Germany, October 3, 2008.
9. Workshop on HPTLC Applications. CAMAG, Riyadh, KSA, May 18,
2008.
10. The EU 7 th Framework Programme for Research & Technological
Development – Opportunities for Researchers in Saudi Arabia, King
Abdulaziz City for Science & Technology, Riyadh, KSA, April 15, 2008.
11. Training Course in Basic Statistics and Statistical Data Treatment Using
SPSS Software, King Saud University, Riyadh, KSA, February 23-27,
2008.

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Curriculum Vitae, Page 10 of 26
12. Training Course in Parametric and Non-Parametric Statistical Treatment
Using SPSS Software, King Saud University, Riyadh, KSA, March 1-5,
2008.
13. Training Course in Chromatography: Old and New Thin-Layer
Chromatography Technique. CAMAG, Riyadh, KSA, May 22, 2006.
14. Workshop on How to Prepare Projects for the Development of Higher
Education- Unit Projects Management– Assiut University, Assiut-Egypt,
September 16, 2003.
15. Workshop in Computer Aided-Drug Design, Faculty of Pharmacy, Ain
Shams University, Cairo-Egypt, April 16-17, 2003.
16. Workshop in Using and Applications of Microcalorimetry, Faculty of
Pharmacy, University of Utah, Salt Lake City-Utah, USA, May 15, 2001.
17. Workshop in Using Differential Scanning Calorimeter, Faculty of
Pharmacy, Assiut University, Assiut-Egypt, November 26, 1998.
18. Training course in molecular biology, Assiut University Genetic
Engineering & Molecular Biology Research Center, Assiut-Egypt, May 3-
6, 1997.
19. An Intensive Training Course on Operating Systems and Macintosh
Computers and Programs Alenashralmketbi (Imagstar) - A National Group
of The Computer Services, Cairo-Egypt, April 1994.
20. Training Course on Introduction to PC Operating Systems and
Programming Assiut University Computer Center, Assiut –Egypt, October
28-November 11, 1990.
Projects:
1. Investigator in a project of Development of Immunochemistry-Based
Nanosensors for Measuring Cancer Markers in Biological Specimens
(1,685,200 Saudi Riyals), September 2010- October 2012.
2. PI in a project of Design and Synthesis of Combinatorial Library of Some
Schiff Bases of Indolin-2,3-Dione With Potential Antitubercular Activity.
Supported by King Abdulaziz City for Science and Technology (1,650,000
Saudi Riyals), October 2009- September 2011.

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Curriculum Vitae, Page 11 of 26
3. Investigator in a project of Synthesis and In-vitro Antimicrobial Activity of
Tetrahydro-2H-1,3,5- thiadiazin-2-thione Derivatives of Some Abnormal
Amino Acids Supported by College of Pharmacy Research Center/King
Saud University( 50000 Saudi Riyals), 2009-2011.
4. PI in a project of In Vitro Investigations of Biotransformation of Some
Xenobiotics by Human Intestinal Bacteria (HIB). Supported by College of
Pharmacy Research Center/King Saud University( 60000 Saudi Riyals),
2007-2009.
5. Investigator in a project of Immunoanalytical Study for Evaluation of 5-
Methyldeoxycytidine as a Diagnostic Biomarker for Leukemia. Supported
by College of Pharmacy Research Center/King Saud University( 45000
Saudi Riyals), 2007-2009.
6. PI in a project of Synthesis and Investigation of Some Amantadine
Derivatives as Hepatic Delivery System to Enhance its Activity Against
HCV. Supported by College of Pharmacy Research Center/King Saud
University (50000 Saudi Riyals), 2006-2008.
7. Investigator in a project of Synthesis and Investigation of Selenium
Derivatives with Potential Cancer Preventive Activity. Supported by
College of Pharmacy Research Center/King Saud University (60000 Saudi
Riyals), 2006-2008.
8. Investigator in a project of Development of Sensitive Immunoanalytical
Technique for 2'-Deoxycytidine as a Potential Prognostic Marker for Breast
Cancer Chemotherapy. Supported by College of Pharmacy Research
center/King Saud University(50000 Saudi Riyals), 2006-2007.
9. Investigator in a project of An Unusual and Alternative Route for Synthesis
of Chiral 4-Substiruted-N-Arylsulfonyl-2-Imidazolidinones and Their
Antitumor Activity: Molecular Modeling Study. Supported by College of
Pharmacy Research Center/King Saud University(45000 Saudi Riyals),
2006-2008.
10. Investigator in a project of Methods and Compositions Related to
Eosinophil Regulation. In collaboration with Department of Dermatology
and Immunology, School of Medicine - University of Utah/USA.
Supported by University of Utah (October 2004- August 2005).
11. Investigator in a project of Synthesis of Preparation of prodrugs and conjugates
of thiol- and selenol-containing compounds and Methods of Use Thereof. In
collaboration with Department of Medicinal Chemistry, College of

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 12 of 26
Pharmacy - University of Utah/USA. Supported by NIH (February 2004-
August 2005).
12. Investigator in a project of Synthesis of Homogenous Oligoribonucleotides with
Potent Anti-HIV Activity. In collaboration with Department of Medicinal
Chemistry, College of Pharmacy - University of Utah/USA. Supported by
NIH (May 2001- November 2002).
13. Investigator in a project of Synthesis of Selective Dopamine Receptors (D4)
Agents with Potential Antipsychotic Activity. In collaboration with
Department of Medicinal Chemistry, Institute of Pharmaceutical and Food
Chemistry, Emil Fischer Center, Friedrich-Alexander University, Germany.
Supported by the Deutsche Forschungsgemeinschaft, the BMBF, the Fonds
der Chemischen Industrie and Deutsche Academic Exchange Program
(DAAD), (September 1999- December 1999).
14. Investigator in a project of Synthesis of A Structurally Simplified Analogue of
the Antibiotic Heptelidic Acid. In collaboration with Institute of
Pharmaceutical Chemistry - University of Vienna/Austria. Supported by
Austrian Scientific Exchange Program (FWF), (December 1997- August
1998).
Reviewing and Editorial Boards of Journals and Scientific Authorities
1. European Journal of Medicinal Chemistry.
2. Journal of Heterocyclic Chemistry.
3. Chemical Biology & Drug Design
4. Archiv der Pharmazie.
5. Archives of Pharmacal Research.
6. Journal of Pharmacy & Pharmaceutical Sciences.
7. Journal of Biotechnology.
8. Medicinal Research Reviews.
9. Expert Opinion on Drug Discovery.
10. TURKISH JOURNAL OF CHEMISTRY
11. Saudi Pharmaceutical Journal.
http://www.elsevier.com/wps/find/journaleditorialboard.cws_home/7
22878/editorialboard
12. Journal of Saudi Chemical Society

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 13 of 26
13. International Journal of Biomedical Sciences.
14. Scienta Pharmaceutica.
15. Scientific Research and Essays (SRE).
16. Natural Science
http://www.scirp.org/Journal/EditorialBoard.aspx?JournalID=69
17. Journal of Biochemistry & Pharmacology
http://www.omicsgroup.org/journals/editorialboardBCPC.php#
18. Journal of Liquid Chromatography & Related Technologies
19. E-Journal of Chemistry
20. Mini-Reviews in Medicinal chemistry
21. Journal of Zhejiang University-SCIENCE B
22. King Abdulaziz City for Science and Technology (KACST)- Saudi
Arabia.
23. King Abdulaziz University Research Center – Saudi Arabia
24. Research Center of the College of Pharmacy-King Saud University-
Saudi Arabia.
25. Taif University Research Center – Saudi Arabia
Mailing Address:
(Office, Mailing address) :
Department of Medicinal Chemistry, Faculty of Pharmacy, Assiut University,
Assiut 71526, Egypt.
Voice: (+20) 882-411321 (Office)
(+20) 1204-339446 (Mobile)
Fax. (+20) 882- 332776 / 312564
EMail : Fadl@ Aun.Edu.Eg
Web site: http://www.aun.edu.eg/membercv.php?M_ID=2758
(Residence) :
Makkha Street, El-Diaa Tawer, Flat No. 7, Assiut 71111, Egypt.
Tel: (+20) 882-318-552

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 14 of 26
List of Publications
1. Patents:
1. Prodrugs and Conjugates of Thiol-and Selenol-Containing Compounds and
Methods of Use Thereof. . Michael R. Franklin, Jeanette Roberts, Tarek
Aboul-Fadl, U.S. Pat. No.: US 7,425,635 B2, Sep. 16 2008.
http://www.patents.com/Prodrugs-conjugates-thiol--selenol-containingcompounds-methods-thereof/US7425635/en-US/
2. Methods and Compositions Related to Eosinophil Regulation. Lori
A.Wagner, Katrin Szardenings, Gerald J. Gleich, Tarek Aboul-Fadl. The
World Intellectual Property Organization ( WIPO), 2007.
http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007136707&
F=0)
3. New Selenium Containing Compounds Useful to Treat e.g. Cancer,
Diabetes, Crohn's Disease, Ulcerative Colitis, Viral Infection and Parasitic
Infection. Michael R. Franklin, Jeanette Roberts, Tarek Aboul-Fadl.
WO2006076337-A1, July 20, 2006.
http://apps.isiknowledge.com/full_record.do?product=UA&search_mode=
GeneralSea.
4. Novel N,N'-Hydrazino-bis-isatin Derivatives with Selective Activity
Against Multidrug-Resistant Cancer Cells. Tarek Aboul-Fadl, Adnan
Ahmed Kadi, Hatem Abdel-Khader Abdel-Aziz. WO 7775566111 , March
31, 2011.
5. Novel and Potent Anti-TB Agent of Isatin derivatives. Tarek Aboul-Fadl,
Fayzah bint Ahmad S. Bin Jubair. U.S. Patent Number 13/081,521. April
7, 2011.
6. Isatin derivatives and their use in therapy. Tarek Aboul-Fadl, EP 11 193
462.6, December 14, 2011.
7. Amide Amino Acid Esters of Nonsteroidal Anti-Inflammatory Drugs
(NSAIDs) as Potent Inhibitors of Colon Tumor Cell Growth. Tarek
Aboul-Fadl, Suliman Saud Al-Hamad, Abdel-Rahman M. Al-Obaid, Gary
Pizza. EP 12153878.9, February 3, 2012.

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Curriculum Vitae, Page 15 of 26
3. Published articles :
1. Design, Synthesis and Pharmacophoric Model Building of Novel Substituted
Nicotinic Acid Hydrazones with Potential Antiproliferative Activity. Hatem A.
Abdel-Aziz, Tarek Aboul-Fadl, Abdul-Rahman M. Al-Obaid, Mohamed
Ghazzali, Abdullah Al-Dhfyan and Alessandro Contini. Archives of Pharmacal
Research, (2011). (In Press)
2. Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative
activity, Tarek Aboul-Fadl, Awwad A. Radwan, Mohamed Attia, Abdullah Al-
Dhfyan, Hatem A. Abdel-Aziz. Chemistry Central Journal, 6, 49(2011).
doi:10.1186/1752-153X-6-49.
3. Novel Schiff bases of indoline-2,3-dione and nalidixic acid hydrazide:
synthesis, in vitro antimycobacterial and in silico mycobacterium tuberculosis
(mtb) DNA gyrase inhibitory activity. Tarek Aboul-Fadl, Awwad A. Radwan,
Hatem A. Abdel-Aziz, Mohd. Baseeruddin, Mohamad I. Attia and Adnan
Kadi. Digest Journal of Nanomaterials and Biostructures, 7, 329-338 (2012).
4. 3,5-Disubstituted Thiadiazine-2-thiones: A New Cell-Cycle Inhibitors. Awwad
A. Radwan, Abdullah Al-Dhfyan, Mohammed K. Abdel-Hamid, Abdullah A.
Al-Badr and Tarek Aboul-Fadl. Archives of Pharmacal Research, 35, 35-
49(2011).
5. Amantadine Amides Prodrugs as Hepatic Delivery Systems to Enhance its
Activity Against HCV. Tarek Aboul-Fadl, Mahmoud M. Sheha, Adel S. El-
Azab, Hatem A. Abdel-Aziz. Digest Journal of Nanomaterials and
Biostructures, 6, 1675-1683(2011).
6. Schiff Bases of Indoline-2,3-Dione: Potential Novel Inhibitors of
Mycobacterium Tuberculosis (Mtb) DNA Gyrase. Tarek Aboul-Fadl, Hatem
A. Abdel-Aziz, Mohammed K. Abdel-Hamid, Tilal Elsaman, Jane Thanassi
and Michael J. Pucci. molecules,16,7864-7879 (2011).
7. (Z)-Ethyl 2-cyano-2-(2-(5,6-dimethyl-4-(thiophen-2-yl)- 1H-pyrazolo[3,4-b]pyridin-
3-yl)hydrazono)acetate.Hoong-Kun Fun, Madhukar Hemamalini, Hatem A. Abdel-
Aziz and Tarek Aboul-Fadl. Acta Crystallographica Section E, 67, o2145–
o2146 (2011).
8. Microwave-Assisted Solution-Phase Synthesis and DART-Mass Spectrometric
Monitoring of Combinatorial Library of Indolin-2,3-Dione Schiff Bases with

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 16 of 26
Potential Antimycobacterial Activity. Tarek Aboul-Fadl, Hatem A. Abdel-Aziz,
Adnan Kadi, Pervez Ahmad, Tilal Elsaman, Mohamed W. Attwa and Ibrahim A.
Darwish. molecules,16, 5194-5206 (2011).
9. Microwave-assisted, One-step Synthesis of Fenamic Acid Hydrazides
from Their Acids. Tarek Aboul-Fadl, Hatem A. Abdel-aziz, Adnan Kadi,
Ahmed Bari, Pervez Ahmad, Tilal Al-samani, Seik Weng Ng. molecules,16,
3544-3551 (2011).
10. Cell Screening Assay for Identifying Inhibitors of Eosinophil Proliferation.
Jessica J. Kempe-Dustin, Tarek Aboul-Fadl, Clarissa Christensen, Robert
Palais, Krishna Parsawar, Gerald J. Gleich, and Lori A. Wagner. Drug
Development Research, 72(4), 353-360 (2011).
11. (Z)-3Hydrazinylidene-1-phenylindolin-2-one. Hatem A. Abdel-Aziz,
AhmedBari, T. Aboul-Fadl and Seik Weng Ng. Acta Crystallographica
Section E, 66(Pt 11): o3014(2010)
12. Effects of Isatin-Isoniazid Derivatives on Drug Metabolizing and
Chemoprotective Enzymes in Mice. Wael M. El-Sayed, Tarek Aboul-Fadl,
and Michael R. Franklin. Drug Development Research, 71, 313-322(2010).
13. Schiff Bases of Indoline-2,3-dione (Isatin) Derivatives and Nalidixic Acid
Carbohydrazide, Synthesis, Antitubercular Activity and Pharmacophoric
Model Building. Tarek Aboul-Fadl, Fayzah A. S. Bin-Jubair and Omima
Aboul-Wafa. Eur. J. Med. Chem. 45, 4578-4586 (2010).
14. Cell Cycle Disruption and Apoptotic Activity of 3-Aminothiazolo[3,2-
a]benzimidazole-2-carbonitrile and its homologues. Abdelwareth A. O. Sarhan,
Abdullah Al-Dhfyan, Maha A. Al-Mozaini, Chaker N. Adra, and Tarek Aboul-
Fadl. Eur. J. Med. Chem., 45, 2689-2694(2010).
15. Anti-Tubercular Activity of Isatin Derivatives. Tarek Aboul-Fadl and Fayzah
A. S. Bin-Jubair. Int. J. Res. Pharm. Sci. 1(2),113-126 (2010).
16. New Sensitive HPLC Method for Evaluation of the Pharmacokinetics of New
Amantadine Prodrugs as Hepatic Delivery Systems to Enhance its Activity
against HCV. Ibrahim A. Darwish, Tarek Aboul-Fadl, Nasr Y. Khalil, Ashraf
M. Mahmoud, Abdul-Rahman M. Al-Obaid. Int. J. Res. Pharm. Sci. 1(2),151-
151 (2010).
17. Pharmacophoric Model Building for Antitubercular Activity of the Individual
Schiff Bases of Small Combinatorial Library. Wesam S. Abdel-Aal, Hoda

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 17 of 26
Y.Hassan, Tarek Aboul-Fadl and Adel F. Youssef, Eur. J. Med. Chem., 45,
1098-1106(2010).
18. Solution-Phase Synthesis of Small Schiff Bases Combinatorial Library with
Potential Antitubercular Activity. Wesam S. Abdel-Aal, Hoda Y.Hassan,
Tarek Aboul-Fadl and Adel F. Youssef, Der Pharma Chemica, 1, 1-13(2009).
19. Selective Spectrophotometric and Fluorometric Method for the Determination
of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with
Sodium 1,2- Naphthoquinone-4-Sulphonate. Ashraf M. Mahmoud, Nasr Y.
Khalil, Ibrahim A. Darwish, Tarek Aboul-Fadl, Intl. J. Anal. Chem, 1-
9(2009).
20. A highly sensitive enzyme immunoassay for evaluation of 2_-deoxycytidine
plasma level as a prognostic marker for breast cancer chemotherapy. Ibrahim
A. Darwish, Ashraf M. Mahmoud, Tarek Aboul-Fadl, Abdul-Rahman A. Al-
Majed, Nasr Y. Khalil. Analytica Chimica Acta, 632, 266–271(2009).
21. Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-mercaptopurine
Base. Tarek Aboul-Fadl, Gopalan Rajeev Kallanthottathil and Arthur D.
Broom. J. Heterocyclic Chem., 45,445-451(2008).
22. Pre- and post-initiation chemoprevention activity of 2-alkyl/aryl
selenazolidine-4(R)-carboxylic acids against tobacco-derived nitrosamine
(NNK)-induced lung tumors in the A/J mouse. M. R. Franklin, P. J. Moos, W.
M. El-Sayed, T. Aboul-Fadl, J.C. Roberts. Chem-Biol Interactions, 168, 211–
220(2007).
23. Murine Hepatoma (Hepa1c1c7) Cells: A Responsive In Vitro System for
Chemoprotective Enzyme Induction by Organoselenium Compounds. Wael M.
El-Sayed, Tarek Aboul-Fadl, Jeanette C. Roberts, John G. Lamb and Michael
R. Franklin. Toxicology in Vitro, 21, 157-164(2007).
24. Antisense Oligonucleotide Technologies in Drug Discovery. Tarek Aboul-
Fadl, Expert Opin. Drug Discov. 1, 285-288(2006).
25. Sensitivity of Escherichia coli to L-selenaproline and other L-proline
analogues in laboratory culture media and normal. human urine Charles
Deutch, Maria Arballo, Latoya Cooks, Jenny Gomes, Tiara Williams,
Tarek Aboul-Fadl and Jeanette Roberts, Letters in Applied Microbiology 43,
392–398(2006).

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 18 of 26
26. Acute Effects of Novel Selenazolidines on Murine Chemoprotective Enzymes.
Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts,
and Michael R. Franklin. Chemico-Biological Interactions, 162, 31-42 (2006).
27. The Utility and Synthetic Uses of Mannich Reaction: An efficient Route for
Synthesis of Thiadiazino-[1,3,5][3,2-a]Benzimidazoles. Abdel-Wareth A.O.
Sarhan, Shams H. Abdel-Hafez, Hassan El-Sherif and Tarek Aboul-Fadl,
Synthetic Communications, 36, 987 - 996 (2006).
28. Effect of selenium-containing compounds on hepatic chemoprotective
enzymes in mice. Wael M. El-Sayed, Tarek Aboul-Fadl, John G. Lamb,
Jeanette C. Roberts, Michael R. Franklin,Toxicology, 220, 179–188 (2006)
29. Synthesis of 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid
Derivatives of Potential Anti-inflammatory Activity. Safwat M. Rabea, Nawal
A. El-Koussi, Hoda Y. Hassan, Tarek Aboul-Fadl, Archiv der Pharmazie,
339, 32-40(2006).
30. Preparation of prodrugs and conjugates of thiol- and selenol-containing
compounds. Michael R. Franklin, Jeanette Roberts, Tarek Aboul-Fadl, U.S.
Pat. Appl. Publ. (2005), 20 pp
31. Selenium Derivatives as Cancer Preventive Agents. ‘A Review Article’.
Tarek Aboul-Fadl, Current Medicinal Chemistry-Anti-Cancer Agents, 5, 637-
52 (2005).
32. Antisense Oligonucleotides: The State of the Art ‘A Review Article’. Tarek
Aboul-Fadl, Current Medicinal Chemistry, 12, 2193-2214(2005).
33. Synthesis and Antitubercular Activity of Some Mannich bases Derived from
Isatin Isonicotinic acid hydrazone. Mostafa A. Hussein, Tarek Aboul-Fadl
and Asmaa Hussein, Bull. Pharm. Sci., Assiut University, 28, 131-136 (2005).
34. An Unusual “Senseless” 2’-5’ Oligoribonucleotide with Potent Anti-HIV
Activity. Tarek Aboul-Fadl, Vijai K. Agrawal, Robert W. Buckheit Jr. and
Arthur D. Broom, Nucleosides, Nucleotides & Nucleic Acids, 23, 545-
554(2004).
35. Optical Isomers of 3-substituted-5-(2-carboxyethyl)-1,3,5- thiadiazin-2-thiones
of Potential Antimicrobial Activity, Synthesis, and Solid State Stability.
Mostafa A. Hussein, Tarek Aboul-Fadl, Mahrous Osman, Mohamed Hassan
and Mohamed Hashem, Egyptian J. of Biomedical Sciences,, 16, 194-
209(2004).

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 19 of 26
36. Synthesis, Antitubercular Activity and Pharmacokinetic Studies of Some
Schiff Bases Derived from 1- Alkylisatin and Isonicotinic Acid Hydrazide
(INH). Tarek Aboul-Fadl, Fargany A. Mohammed and Ehssan A. Hassan,
Archives of Pharmacal Research, 26, 778-784 (2003).
37. 1,2-Dihydroisoquinoline-N-Acetic Acid Derivatives as New Carriers for
Specific Brain Delivery I : Synthesis and Estimation of Oxidation Kinetics
Using Multivariate Calibration Method,Sahar Mahmoud, Tarek Aboul-Fadl,
Mahmoud Sheha, Hassan H. Farag and Abdel-Maboud I. Mouhamed, Arch.
Pharm.Pharm. Med. Chem., 336, 573-584 (2003).
38. 1,2-Dihydroisoquinoline-N-acetic acid Derivatives as New Carriers for Brain
Specific Delivery II: Delivery of Phenethylamine as Model Drug, Sahar
Mahmoud, Mahmoud Sheha, Tarek Aboul-Fadl, and Hassan H. Farag,
Arch. Pharm.Pharm. Med. Chem.,336, 526-531(2003).
39. Synthesis, Degradation kinetics and In-vitro Antimicrobial Activity of
Tetrahydro-2H-1,3,5- thiadiazine-2-thione Derivatives of Some -Amino
Acids, Tarek Aboul-Fadl and Abdel-Raouf Khallil, Arzneim-Forsch./Drug
Res., 526-531(2002).
40. Tetrahydro-2H-1,3,5- thiadiazin-2-thione Derivatives of The optical Isomers of
Phenylalanine, Synthesis, Comparative Stability Study and Antifungal
Activity, Tarek Aboul-Fadl, and Mahrous Osman, Sci. Pharm., 70, 359-
378(2002).
41. New 2H-Tetrahydro-1,3,5-thiadiazine-2-thiones Incorporating Glycine and
Glycinamide as Potential Antifungal Agents, Tarek Aboul-Fadl, Mostafa A.
Hussein, Abdel-Nasser El-Shorbagi, and Abdel-Raouf Khallil, Arch.
Pharm.Pharm. Med. Chem.,335, 438-442(2002).
42. Kinetics of solid state stability of glycine derivatives as a model for peptides
using differential scanning calorimetry, Mostafa I. Abd-Elrahman, Mahrous O.
Ahmed, Sayed M. Ahmed, Tarek Aboul-Fadl and A.El-Shorbagi, Biophysical
chemistry, 19, 113-20(2002).
43. Di- and Trisubstituted Pyrazolo[1,5-a]pyridine Derivatives: Synthesis,
Dopamine Receptor Binding and Ligand Efficacy. Stefan Löber, Tarek
Aboul-Fadl, Harald Hübner and Peter Gmeiner, Bioorganic and Medicinal
Chemistry Letters, 12, 633-636(2002).

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 20 of 26
44. New Paeonilactone-A-Adducts Formed by Incubation of Paeoniflorin with
Lactobacillus brevis in Presence of Arylthiols, Atef A. Abdel-Hafez, Meselhy
R. Meselhy, Norio Nakamura, Masao Hattori, Mahmoud A. El-Gendy, Nadia
M. Mahfouz and Tarek A. Mohamed, Chem. Pharm. Bull., 49, 918-
920(2001).
45. Antigiardial Activity of Metronidazole Twin Ester Prodrugs. Ahmed K. Dyab
and Tarek Aboul-Fadl, Zagazig University Medical Journal, VII(5), 1268-
1275(2001).
46. Investigation of Alkylating, Antineoplastic and Anti-HIV Potentials of the
Chalcones; 2-(3-Arylpropenoyl)benzimidazole and Their Corresponding N1-
Methyl Derivatives. Tarek Aboul-Fadl, Abdel-Nasser El-Shorbagi, Zeinab A.
Hozien and Abdel-Wareth A.O. Sarhan, Bollettino Chimico
Farmaceutico,139, 228-234(2000).
47. Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving
Palladium-Catalyzed Coupling Reactions. Tarek Aboul-Fadl, Stefan Löber
and Peter Gmeiner, Synthesis,12, 1727-1732 (2000).
48. Cyclic amide derivatives as potential prodrugs: N-hydroxymethyl-succinimide-
/isatin esters of some NSAIDs as chemical delivery system with improved
therapeutic index, F.A. Omar, N. M. Mahfouz and T. Aboul-Fadl, Eur. J.
Med. Chem.,34,551-562(1999).
49. Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by
Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus
brevis, A.A. Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H.
Watanabe, Y. Murakami. M. A. El-Gendy, N. M. Mahfouz and T. A.
Mohamed, Biol. Pharm. Bull., 22, 491-497(1999).
50. Tetrahydro-2H-1,3,5-thiadiazin-5-(4-pyridylcarboxamide)-2-thione
Derivatives as prodrugs for Isoniazid, Synthesis, Investigations and In Vitro
Antituberculous Activity, T. Aboul-Fadl and K. Hassanin, Pharmazie, 54,
244-247(1999).
51. Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis,
Characterization and in vitro Stability, T. Aboul-Fadl, M. M. Sheha and S.
Khider, Sci. Pharm., 67, 27-41(1999).
52. Metronidazole Twin Ester Prodrugs II : Non Identical Twin Esters of
Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 21 of 26
Derivatives, T. Aboul-Fadl and N. M. Mahfouz, Sci. Pharm., 66, 309-
324(1998).
53. Esters Twin Drugs of Metronidazole : Synthesis, Physicochemical
properties, Kinetic studies and Antigardial activity, N. M. Mahfouz, T. Aboul-
Fadl and A. K. Diab, Eur. J. Med. Chem., 33, 675-683(1998).
54. Effects of Paeoniflorin Derivatives on the Scopolamine-Induced Amnesia
Using a Passive Avoidance Task in Mice; Structure-Activity Relationship,
Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, Y.
Murakami, M. A. El-Gendy, N. M. Mahfouz and T. A. Mohamed, Biol.
Pharm.Bull., 21, 1174-1174(1998).
55. Paracetamol (Acetaminophen) Esters of Some Non-steroidal Antiinflammatory
Carboxylic acids Drugs as Mutual Prodrugs with Improved
Therapeutic Index., T.A. Fadl and F. A. Omar, Inflammopharmacology, 6,
143-157(1998).
56. Potent Anticonvulsant Paeonimetabolin-I Derivatives Obtained by Incubation
of Paeoniflorin and Sulfhydryl Compounds With Lactobacillus Brevis,
Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori, H. Watanabe, T. A.
Mohamed, N. M. Mahfouz and M. A. El-Gendy, Chem.Pharm. Bull., 46,1486-
1487(1998).
57. New Carriers for Representative Peptide Drugs, T. Aboul-Fadl and A. El-
Shorbagi, Arch. Pharm.Pharm. Med. Chem, 330, 327- 332(1997).
58. Steric Parameters in PLE Catalyzed Hydrolysis of N 4 -substituted Cytarabine
Esters Prodrugs, T. Kawaguchi, A.F.Youssef, T.Aboul-Fadl, F.A.Omar,
H.H.Farag, and T.Hasegawa, Pharmazie, 51, 717-719(1996).
59. New Prodrug Approach for Amino Acids and Amino-Acid-Like Drugs,
T.Aboul-Fadl and A. El-Shorbagi, Eur. J. Med. Chem.,31,165-169(1996).
60. Synthesis and In Vitro Investigation of Nalidixic Acid Amides of Amino Acid
Esters as Prodrugs, T. Aboul-Fadl and E. A. Fouad, Pharmazie, 51, 30-
33(1996).
61. Synthesis and Investigation of N 4 -substituted Cytarabine Derivatives as
Prodrugs, T.A.Fadl, T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and
T.Kawaguchi, Pharmazie, 50, 382-387(1995).

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 22 of 26
62. 1 HNMR and chelating properties of 1,5-dimethyl-N-substituted-1H-pyrazole-
3- carboxamides and 1,3-dimethyl-N-substituted-1H-pyrazole-5-carboxamides,
T.Abo-El-Fadl, A. F. Youssef and A. N. Ahmed, Pharmazie, 48,117-
120(1993).
63. 1 HNMR of Pyrazoles : effect of interaction of carbamoyl group with adjacent
centers on the chemical shifts of concerned protons, T.A. Mohamed, A. F.
Youssef and A. N. Ahmed, Bull. Pharm. Sci., Assiut University, 15, 100-
105(1992).
64. Synthesis and Biological activity of certain 1,3- and 1,5-dimethyl-Nsubstituted
pyrazole carboxamides, T.A. Fadl, A. F. Youssef, A. N. Ahmed
and H. I. El-Bitar, Bull. Pharm. Sci., Assiut University, 13, 145-158(1990).
3. Presentations
1. Novel amino acid derivatives of naproxen for colon cancer chemoprevention.
Tarek Aboul-Fadl, Suliman S. Al-Hamad, Mohammed K. Abdel-Hamid,
Hatem A. Abdel-Aziz, Abdel-Rahman M. Al-Obaid, Jason D. Whitt, Bernard
D. Gary, Adam B. Keeton and Gary A. Piazza . 243rd American Chemical
Society meeting, San Diego, California -USA, March 25-29, 2012.
2. Schiff Bases of Indoline-2,3-dione As Potential Novel Inhibitors of
Mycobacterium tuberculosis (Mtb) DNA Gyrase. Tarek Aboul-Fadl, Hatem
A. Abdel-Aziz, Telal Al-Samani, Pervez Ahmad, Adnan Khadi, Ibrahim
Darwish, Mohammed K. Abdel-Hamid, Jane Thanassi and Michael J. Pucci.
47 th International Conference on Medicinal Chemistry (RICT 2011), Lyon-
France, July 6 -8, 2011.
3. Design and Synthesis of substituted Nicotinic Acid Hydrazones With Potential
Antiproliferative Activity. Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Abdul-
Rahman M. Al-Obaid, Abdullah Al-Dhfyan and Alessandro Contini. The 66 th
Northwest Regional Meeting of The American Chemical Society (NORM
2011), Portland, Oregon-USA, June 26 -29, 2011.
4. Design and Synthesis of a Combinatorial Library of Indoline-2,3-dione Schiff
bases with Potential Anti-tubercular Activity. Tarek Aboul-Fadl, Hatem A.
Abdul-Khader, Adnan Khadi, Ibrahim Darwish, Telal Al-Samani, Pervez
Ahmad, Ahmed Bari and Sahal Al-Hajoj. 46 th International Conference on
Medicinal Chemistry (RICT 2010), Reims-France, June 30 -July 2, 2010.

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 23 of 26
5. Schiff Bases of Indol-2,3-dione (Isatin) Derivatives and Nalidixic Acid
Hydrazidewith Potential Antitubercular Activity. Fayzah A. S. Bint-Jubair,
Omima Aboul-Wafa and Tarek Aboul-Fadl. The 8 th Saudi International
Pharmaceutical Conference and Exhibition, Riyadh-Saudi Arabia, April 26-28,
2010.
6. Antimicrobial and Estrogenic Activity of Ferutinin and Selected Semi-
Synthetic Analogs. Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed,
Desmond Slade, Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and
Mahmoud A. ElSohly, The 50 th Anniversary Meeting of the American Society
of Pharmacognosy, Honolulu, HI-USA, June 27-July 1, 2009.
7. Evaluation of The Pharmacokinetic of New Amantadine Prodrugs As Hepatic
Delivery Systems to Enhance Its Activity Against HCV by A New HPLC
Method. Tarek Aboul-Fadl , Ashraf M. Mahmoud, Nasr Y. Khalil, Ibrahim A.
Darwish and Abdul-Rahman Al-Obaid 237 th American Chemical Society
meeting, Salt Lake City, Utah-USA, March 22-26, 2009.
8. Preparation, Antimicrobial and Estrogenic Activity of Ferutinin and Selected
Analogs. Ahmed Galal, Safwat Ahmed, Ehab A. Abourashed, Desmond Slade,
Waseem Gul, Shabana Khan, Tarek Aboul-Fadl and Mahmoud A. ElSohly,
The annual meeting of the National Center for Natural Products Research of
the University of Mississippi, University of Mississippi-USA, January 2009.
9. Selenium Derivatives as a Cancer Preventive Agents. T. Aboul-Fadl, 2 nd
World Conference on Magic Bullets (Ehrlich II). Nürnberg, Germany, October
3 - 5, 2008.
10. Regulation of ATP-binding cassette (Abc) transporters by organoselenium
compounds. Dorinda D. Arch. Wael M. El-Sayed, Tarek Aboul-Fadl,
Jeanette C. Roberts and Michael R. Franklin. San Diego, California, USA,
April 2008.
11. Chemoprevention in mice by 2-alkyl/aryl selenazolidine-4(R)-carboxylic acids.
M.R. Franklin, J.C. Roberts, W.M. El-Sayed, T. Aboul-Fadl, T. Schofield,
J.E. Constance and J.G. Lamb. The 46 th Annual Meeting (SOT), Charlotte,
NC-USA, March 2007. Abstract 609, Toxicological Sciences p126S.
12. Design, Synthesis and Antitubercular Evaluation of Small Schiff Base
Combinatorial Library. Wesam S. Abd-el Aal, Hoda Y. Hassan, Tarek Aboul-
Fadl , Adel F. Youssef. The 7 th International Saudi Pharmaceutical
Conference. Riyadh-Saudi Arabia, March 19-21 2007.

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 24 of 26
13. Effects of acute exposure of selenazolidines prodrugs of L-selenocysteine on
chemoprotective enzymes in mice and Hepa1c1c7 cells. Wael M. El-Sayed,
Tarek Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R.
Franklin. The 45th Annual Meeting of the Society of Toxicology (SOT), San
Diego, California-USA, March 5-9, 2006.
14. The biological effects of selenocysteine prodrugs. Wael M. El-Sayed, Tarek
Aboul-Fadl, John G. Lamb, Jeanette C. Roberts and Michael R. Franklin,
Annual Bioscience Symposium, University of Utah, Salt Lake City, Utah-USA,
September 9, 2005.
15. Uptake of L-Selenaproline by the L-Cystine Transport System in Escherichia
coli,C. E. Deutch, M. E. Arballo, L. N. Cooks, J. M. Gomes, T. M. Williams,
T. Aboul-Fadl, and J. C. Roberts. 105 th General Meeting of the American
Society for Microbiology, Atlanta, Georgia, USA, June 5-9, 2005.
17. Hepatic effects of novel selenazolidine prodrugs of selenocysteine developed
as potential cancer chemopreventive agents, Tarek Aboul-Fadl, Wael M. El-
Sayed, Tenley Schofield, Jonathan Constance, John G. Lamb, Jeanette C.
Roberts, and Michael R. Franklin. 229th ACS National Meeting, San Diego,
California, USA, March 13-17, 2005.
18. Phase II Drug Metabolizing Enzyme mRNA Changes by Novel Selenazolidine
Prodrugs of Selenocysteine in Mice, Wael M. El-Sayed, Tarek Aboul-Fadl,
Ronald B. McEwen, Tenley Schofield, John G. Lamb, Jeanette C. Roberts and
Michael R. Franklin, The 22 nd Annual Meeting of the Mountain West Society
of Toxicology (MWSOT), Park City – Utah, USA. September 9-10, 2004. P.18
19. Synthesis of 5-Phenyl-1-(Pyridyl)-1H-1,2,4-triazole-3-Carboxylic Acid
Derivatives of potential Antiinflammatory Activity, Safwat M. Rabea,Tarek
Aboul-Fadl, Nawal A. El-Koussi and Hoda Y. Hassan, Assiut University 4 th
Pharmaceutical Sciences Conference, Assiut - Egypt. March 6-7, 2004. P.122
20. Synthesis and Antitubercular Activity of some Schiff Bases Derived from
Mannich Bases of Isatin and Isonicotinic Acid Hydrazide (INH), Mostafa
Hussein, Tarek Aboul-Fadl and Asmaa Abdel-Nasser, Polish-Austrian-
German-Hungarian-Italian Joint Meeting on Medicinal Chemistry, KrakÓw,
Poland 15-18 October 2003.
21. Unusual “Senseless” 2’-5’ Oligoribonucleotide with a Potent Anti-HIV
Activity, Tarek Aboul-Fadl, Vijai Agrawal, Robert W. Buckheit Jr and Arthur
D. Broom, The 1 st International Congress of Pharmaceutical and Drug

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 25 of 26
Industries Division, National Research Center, Cairo-Egypt, March 24-
26(2003).p.118
22. Synthesis of a Peptide Nucleic Acid with a Novel 1-Methyl-6-thiopurine Base,
Tarek Aboul-Fadl, K.G. Rajeev and A.D. Broom, 223 ACS meeting, Orlando,
Florida-USA, April 6-11 (2002).
23. 1,2-Dihydroisoquinoline Derivatives as New Carrier for Brain Specific
Delivery, Sahar M. Mohamoud, Mahmoud M. Sheha, Tarek Aboul-Fadl and
Hassan H. Farag, Assiut University Third Pharmaceutical Sciences Conference,
Assiut-Egypt, March 5-6 (2002)
24. Synthsis of New Optically Active Thiadiazine-2-thione Derivatives as
Antifungal Agents, M.A. Hussein and T. Aboul-Fadl, 8 th IBN SINA
Intrnational Conference on Pure and Apllied Heterocyclic Chemistry, Luxor-
Egypt, Feb. 16-19 (2002).
25. Synthesis and Antifungal Activity of Some New 3,5-Disubstiuted Tetrahydro-
2H-1,3,5-Thiadiazine-2-Thione, T. Aboul-Fadl, M.A. Hussein and A. A. El-
Shorbagi, XXVII Conference of Egyptian Pharmaceutical Society, Cairo -
Egypt, January 2-4 (2001), P.57.
26. Synthesis of 7-Substituted 3-[4(4-Chlorophenyl)-Piperazin-1-ylmethyl]-
Pyrazolo[1,5-a]Pyridine Derivatives as Potential D4-Receptor Ligands, T.
Aboul-Fadl, S. Löber and P. Gmeiner, XXVII Conference of Egyptian
Pharmaceutical Society, Cairo - Egypt, January 2-4(2001), P. 56.
27. Chitosan Conjugates of Ibuprofen and Flurbiprofen: Synthesis,
Characterization and in vitro Stability, T. Aboul-Fadl, M. M. Sheha and S.
Khider, XXVI Conference of Egyptian Pharmaceutical Society, Cairo- Egypt,
December 8-10(1998), p. 31.
28. Flow injection analysis of amino acids using Cu(II) oxide as a packed reactor
for ultraviolet detection, S. Emara and T. Aboul-Fadl, Fourth European
Congress of Pharmaceutical Sciences, Milan-Italy, September 11-13(1998).
29. Cyclic amide derivatives as potential prodrugs: N-hydroxmethyl-succinimide-
/isatin esters of some NSAIDs as chemical delivery system with improved
therapeutic index, F. A. Omar, N. M. Mahfouz and T. Aboul-Fadl, XIV
Scientific Meeting of the Austrian Pharmaceutical Society, Graz - Austria, June
11-13(1998), p. S85.

Tarek Aboul-Fadl, Ph.D.
Curriculum Vitae, Page 26 of 26
30. A Structurally Simplified Analogue of the Antibiotic Heptelidic Acid With a
Five Membered Carbocyclic Ring, T. Aboul-Fadl, W. Fleischhacker and E.
Urban, XIV Scientific Meeting of the Austrian Pharmaceutical Society, Graz -
Austria, June 11-13(1998), p. S15.
31. Acetaminophen Esters of Some Non-steroidal Antiinflammatory Drugs as
Mutual Prodrugs with Improved Therapeutic Index, T. A. Fadl and F. A.
Omar, Assiut University First International Pharmaceutical Sciences
Conference, Faculty of Pharmacy, Assiut-Egypt, March 4-5(1998), p. 3.
32. Metronidazle Twin Esters Prodrugs II : Non Identical Twin Esters of
Metronidazole and Some Antiprotozoal Halogenated Hydroxyquinoline
Derivatives, T. Aboul-Fadl, N. M. Mahfouz and A. K. Diab, Assiut University
First International Pharmaceutical Sciences Conference, Faculty of Pharmacy,
Assiut-Egypt, March 4-5(1998), p. 1.
33. Modifications of Paeoniflorin and Paeonimetabolin I by Chemical and
Biochemical Means, Abdel-Hafez, M. R. Meselhy, N. Nakamura, M. Hattori,
H. Watanabe, T. A. Mohamed, N. M. Mahfouz and M. A. El-Gendy,
International Symposium on Natural Medicines, Kyoto - Japan, October 28
-30(1997), p. 3P-032.
34. Tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives as new carriers for peptide
drugs, T. Aboul-Fadl and A. El-Shorbagi, XXV Conference of Egyptian
Pharmaceutical Society, Cairo- Egypt, December 24-26(1996), p. 68.
35. Synthesis and Investigation of the Alkylating Potential of 2-(3-Arylpropenoyl)benzimidazole
and their Corresponding N1-methyl Derivatives, T. Aboul-
Fadl, A. El-Shorbagi, Z. Hozein and A. Sarhan, Al-Azhar First International
Conference on Recent Advances in Pharmaceutical Technology and Biological
Sciences, Cairo - Egypt, December 19-21(1995), p. 95.
36. Synthesis, Hydrolysis Kinetics, Lipophilicity, and Biological Activity of N 4 -(3-
Alkoxy and Benzyloxycarbonylpropionyl)-Ara-C Prodrugs, T.A.Fadl,
T.Hasegawa, A.F.Youssef, H.H.Farag, F.A.Omar and T.Kawaguchi, World
congress of Pharmacy and Pharmaceutical Sciences "FIP'93", Tokyo, Japan,
September 5-10(1993), Abstract No. S098.
37. 1 HNMR and chelating properties of 1,5-dimethyl-N-substituted -1H- pyrazole-
3-carboxamides and 1,3-dimethyl-N-substituted-1H- pyrazole-5-
carboxamides,T.A. Fadl, A. F. Youssef, A. N. Ahmed, 3 rd IBN SINA
Symposium on Heterocyclic Chemistry, Aswan, Egypt, January 28-31(1991),
p. 126.