Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
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Infected individuals may be asymptomatic. Symptoms/signs of the disease may include hemolysis,<br />
high fever, chills, muscle aches/arthralgias, headache, fatigue, loss of appetite,<br />
nausea and vomiting. More extreme expressions of disease include hypotension, hepatic<br />
dysfunction, renal failure, disseminated intravascular coagulation, multiorgan failure and<br />
death.<br />
Supportive laboratory findings may include hemolysis, thrombocytopenia, and elevated LFTs.<br />
Treatment:<br />
According to the CDC, most patients who are asymptompatic do not require treatment. Early<br />
diagnosis and treatment of symptomatic patients may reduce the length of illness and severity<br />
of disease. CDC recommendations include assistance from infectious disease specialists<br />
and antimicrobial drugs: Atovaquone + azithromycin for mild to moderate cases or<br />
Clindamycin + quinine for severe cases, usually for 7-10 days, although repeat treatment or<br />
monitoring of parasitemia may be necessary for some patients (immunocompromised, for<br />
example). Please see CDC or MDH web sites for dosing recommendations.<br />
Additionally, those patients with severe illness may require or benefit from supportive care<br />
such as: vasopressors, antipyretics, blood transfusions, exchange transfusions, dialysis, and<br />
mechanical ventilation.<br />
Laboratory Diagnosis:<br />
Bear in mind that some patients may be simultaneously infected with more than one tickborne<br />
infection.<br />
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