Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
Human (Granulocytic) Anaplasmosis (HGA ... - Allina Health
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Morules in neutrophils indicated by arrows<br />
Other pathologic findings include infiltrates of foamy macrophages in reticuloendothelial organs,<br />
multiorgan perivascular lymphohistiocytic infiltrates, and focal hepatocellular apoptosis<br />
(reflecting the hepatocellular injury manifesting as elevated liver function tests (LFTs)).<br />
Treatment:<br />
The first-line treatment for adults and children of all ages, as recommended by the CDC, is<br />
doxycycline. Treatment should be initiated immediately whenever <strong>HGA</strong> is suspected. For patients<br />
who are allergic to doxycycline or have other contraindications, alternative antibiotic<br />
treatment should be considered (see CDC for recommendations and doses). However,<br />
prophylactic antibiotic treatment following a tick bite in an individual who has not developed<br />
disease is not recommended, since there is no evidence that this is effective.<br />
3