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Rheumatoid Arthritis

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Mechanisms of joint damage<br />

• Synovial mass stretches joint capsule and<br />

ligaments: joint swelling, instability &<br />

deformity<br />

• Cytokine and proteolytic enzyme rich synovial<br />

fluid destroys cartilage joint space<br />

narrowing on X-rays<br />

• Infiltration of cartilage and later bone by<br />

invading synovium (pannus)<br />

marginal erosions

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