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BR2: inf. RN1HG BR2: inf. RN1HG BR1: inf. RN1HG ΔsigB BR1+2: inf. RN1HG ΔsigB BR2: inf. RN1HG ΔsigB BR2: inf. RN1HG ΔsigB BR2: inf. RN1HG ΔsigB Maren Depke Results Kidney Gene Expression Pattern in an in vivo Infection Model BR1+2: inf. RN1HG BR1: inf. RN1HG BR2: inf. RN1HG BR1: inf. RN1HG BR1: inf. RN1HG ΔsigB BR2: sham inf. (NaCl) BR2: sham inf. (NaCl) Fig. R.2.4: Scatter plots comparing mean signal intensities of treatment groups. The signals of the three groups “infection with RN1HG”, “infection with RN1HG ΔsigB”, and “sham infection / NaCl control” are plotted separately for biological replicates (BR1, BR2) or combined for both biological replicates (BR1+2). Control sequences and sequences that were absent on all of the arrays used for each scatter plot are not shown. (Absence of expression is defined via a p-value > 0.01 on intensity profile level in Rosetta Resolver). Numbers in the first column refer to the comparison scheme in Fig. R.2.3. 78
Table R.2.1: Genes displaying statistically different expression values in the corresponding comparisons. a The GeneChip Mouse Gene 1.0 ST array contains 35557 sequences (probe sets) of which 6613 are controls (e. g. negative, positive, PolyA, and hybridization controls). The control sequences and sequences that were not expressed on all arrays in the selected group comparison were not included in statistical testing. Maren Depke Results Kidney Gene Expression Pattern in an in vivo Infection Model b Rosetta Resolver software maps the sequences (probe sets) to 20074 EntrezGene records (genes). This mapping is used to calculate the numbers of genes that are significant in statistical testing and when indicated group comparison number of arrays number of sequences absent on all arrays significant with p*
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G E N O M E W I D E C H A R A C T E
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Maren Depke C O N T E N T S GENOMEW
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Maren Depke Z U S A M M E N F A S S
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Maren Depke Zusammenfassung der Dis
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Maren Depke S U M M A R Y O F D I S
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Maren Depke Summary of Dissertation
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Maren Depke I N T R O D U C T I O N
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Maren Depke Introduction Besides op
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Maren Depke Introduction Extracellu
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Maren Depke Introduction with heigh
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Maren Depke Introduction 2005). SaP
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Maren Depke Introduction contains a
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Maren Depke Introduction via fibron
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Maren Depke Results Host Cell Gene
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Maren Depke Results Host Cell Gene
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Maren Depke Results Pathogen Gene E
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S. aureus RN1HG sample conditions a
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mean normalized intensity mean norm
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mean normalized intensity Maren Dep
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log 2 (ratio) log 2 (ratio) log 2 (
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Maren Depke D I S C U S S I O N A N
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Maren Depke Discussion and Conclusi
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Maren Depke References Athanasopoul
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Maren Depke References Byrne GI, Le
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Maren Depke References Demling R. T
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Maren Depke References Foss GS, Pry
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Maren Depke References Hagopian K,
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Maren Depke References Jin T, Bokar
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Maren Depke References Kwan T, Liu
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Maren Depke References Luster AD, U
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Maren Depke References Namiki S, Na
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Maren Depke References Puccetti P.
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Maren Depke References Siewert E, B
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Maren Depke References van den Akke
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Maren Depke References Yang XL, Sch
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Maren Depke A F F I D A V I T / E R
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Maren Depke Acknowledgments Kidney
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