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Maren Depke A C K N O W L E D G M E N T S Many thanks go to all supervisors for the chance to work on this topic, for the mentoring and discussions, and notably for the possibility to use the excellent technical equipment in the Department of Functional Genomics. I like to thank all colleagues for their contribution to cooperation projects, and in particular for the nice working atmosphere, for the support and help in challenging times during this work. And last but not least, sincere thanks are given to all friends and especially to my family for the encouragement and care they gave to me. Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, Ernst-Moritz-Arndt University of Greifswald, Germany Sabine Ameling Marc Burian Dinh Hoang Dang Khoa Melanie Gutjahr … and all other colleagues … Elke Hammer Petra Hildebrandt Ulrike Mäder Marc Schaffer Sandra Scharf Frank Schmidt Leif Steil Uwe Völker Liver gene expression pattern in a mouse psychological stress model Gene expression profiling was performed on mouse samples from a psychological stress model which was established and performed by Cornelia Kiank in the setting of the DFG- Graduiertenkolleg GK840 „Wechselwirkungen zwischen Erreger und Wirt bei generalisierten bakteriellen Infektionen“. After Affymetrix expression profiling method training by Tanja Töpfer and Robert Geffers, array hybridizations were conducted in the lab of the array facility at the Helmholtz-Zentrum für Infektionsforschung. Markus Grube provided the protocol for real-time PCR mastermix. The work was supervised by Christine Schütt, Barbara Bröker, and Uwe Völker. Cornelia Kiank, Christine Schütt, Barbara Bröker (Institute for Immunology and Transfusion Medicine, Department of Immunology, Ernst-Moritz-Arndt University of Greifswald, Germany; C. K. now: David Geffen School of Medicine, UCLA; Digestive Diseases Research Center and Center for Neurobiology of Stress; Los Angeles, CA, USA) Tanja Töpfer, Robert Geffers, Jan Buer, Jürgen Wehland (Helmholtz Centre for Infection Research, Braunschweig, Germany) Markus Grube, Heyo Krömer (Institute of Pharmacology, Ernst-Moritz-Arndt University of Greifswald, Germany) Uwe Völker (Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, Ernst-Moritz-Arndt University of Greifswald, Germany) 237
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G E N O M E W I D E C H A R A C T E
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Maren Depke C O N T E N T S GENOMEW
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Maren Depke Z U S A M M E N F A S S
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Maren Depke Zusammenfassung der Dis
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Maren Depke S U M M A R Y O F D I S
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Maren Depke Summary of Dissertation
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Maren Depke I N T R O D U C T I O N
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Maren Depke Introduction Besides op
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Maren Depke Introduction Extracellu
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Maren Depke Introduction with heigh
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Maren Depke Introduction 2005). SaP
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Maren Depke Introduction contains a
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Maren Depke Introduction via fibron
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Maren Depke Introduction cathelicid
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Maren Depke Introduction shock are
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Maren Depke Introduction STUDIES OF
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Maren Depke Introduction are effect
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Maren Depke Introduction cell stimu
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Maren Depke Introduction channel CF
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Maren Depke M A T E R I A L A N D M
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Maren Depke Material and Methods Li
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Maren Depke Material and Methods Ki
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Maren Depke Material and Methods GE
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Maren Depke Material and Methods Ge
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Pa
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corticosterone [pg/ml plasma] corti
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Maren Depke Results Liver Gene Expr
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lood glucose levels [nmol/l] resist
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LBP [ng/ml] CPR [ng/ml] Maren Depke
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Maren Depke Results Liver Gene Expr
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liver weight [g] Maren Depke Result
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infection rate cfu / 10 mg tissue c
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Maren Depke Results Kidney Gene Exp
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Table R.2.1: Genes displaying stati
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Maren Depke BR1 sign DsigB vs wt BR
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Maren Depke Results GENE EXPRESSION
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Maren Depke Results Gene Expression
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log2(ratio C57BL/6 / BALB/c) at IFN
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Maren Depke Results Host Cell Gene
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Maren Depke Results Pathogen Gene E
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S. aureus RN1HG sample conditions a
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mean normalized intensity mean norm
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mean normalized intensity Maren Dep
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log 2 (ratio) log 2 (ratio) log 2 (
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Maren Depke D I S C U S S I O N A N
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Maren Depke Discussion and Conclusi
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Page 185 and 186: Maren Depke Discussion and Conclusi
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Page 208 and 209: Maren Depke References Athanasopoul
Page 210 and 211: Maren Depke References Byrne GI, Le
Page 212 and 213: Maren Depke References Demling R. T
Page 214 and 215: Maren Depke References Foss GS, Pry
Page 216 and 217: Maren Depke References Hagopian K,
Page 218 and 219: Maren Depke References Jin T, Bokar
Page 220 and 221: Maren Depke References Kwan T, Liu
Page 222 and 223: Maren Depke References Luster AD, U
Page 224 and 225: Maren Depke References Namiki S, Na
Page 226 and 227: Maren Depke References Puccetti P.
Page 228 and 229: Maren Depke References Siewert E, B
Page 230 and 231: Maren Depke References van den Akke
Page 232 and 233: Maren Depke References Yang XL, Sch
Page 235: Maren Depke A F F I D A V I T / E R
Page 239: Maren Depke Acknowledgments Pathoge
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