genomewide characterization of host-pathogen interactions by ...

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Dekan: Prof. Dr. rer. nat. Klaus Fesser 1. Gutachter : Prof. Dr. rer. nat. Uwe Völker 2. Gutachter: Prof. Dr. rer. nat. Christiane Wolz Tag der Promotion: 22. 12. 2010
Maren Depke C O N T E N T S GENOMEWIDE CHARACTERIZATION OF HOST-PATHOGEN INTERACTIONS BY TRANSCRIPTOMIC APPROACHES 1 CONTENTS 3 ZUSAMMENFASSUNG DER DISSERTATION 5 SUMMARY OF DISSERTATION 9 INTRODUCTION 13 INFECTIOUS DISEASES AND IMMUNE SYSTEM 13 Aspects of Innate Immunity 13 Aspects of Adaptive Immunity 16 Modulation of Immune Reactions 18 STAPHYLOCOCCUS AUREUS 20 General Features of S. aureus 20 S. aureus, a Commensal and Opportunistic Pathogen 21 S. aureus Virulence Factors 22 Mechanisms of S. aureus Adaptation to its Environment 28 Increasing Importance and Danger of S. aureus Infections 29 STUDIES OF HOST-PATHOGEN INTERACTIONS 31 Model Systems for Studies of Host Reactions Potentially Influencing the Outcome of Infections 31 Model Systems for Studies of Host-Pathogen Interactions 35 Questions and Aims of the Studies Described in this Thesis 37 MATERIAL AND METHODS 39 LIVER GENE EXPRESSION PATTERN IN A MOUSE PSYCHOLOGICAL STRESS MODEL 39 KIDNEY GENE EXPRESSION PATTERN IN AN IN VIVO INFECTION MODEL 43 GENE EXPRESSION PATTERN OF BONE-MARROW DERIVED MACROPHAGES AFTER INTERFERON-GAMMA TREATMENT 47 HOST CELL GENE EXPRESSION PATTERN IN AN IN VITRO INFECTION MODEL 51 PATHOGEN GENE EXPRESSION PROFILING 55 Growth Media Comparison Study 55 In vitro Infection Experiment Study 57 Tiling Array Expression Profiling 60 3
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Page 7 and 8: Maren Depke Zusammenfassung der Dis
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Page 11 and 12: Maren Depke Summary of Dissertation
Page 13 and 14: Maren Depke I N T R O D U C T I O N
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Pa
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corticosterone [pg/ml plasma] corti
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Maren Depke Results Liver Gene Expr
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lood glucose levels [nmol/l] resist
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LBP [ng/ml] CPR [ng/ml] Maren Depke
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Maren Depke Results Liver Gene Expr
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liver weight [g] Maren Depke Result
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infection rate cfu / 10 mg tissue c
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Maren Depke Results Kidney Gene Exp
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Table R.2.1: Genes displaying stati
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Maren Depke BR1 sign DsigB vs wt BR
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Maren Depke Results GENE EXPRESSION
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Maren Depke Results Gene Expression
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log2(ratio C57BL/6 / BALB/c) at IFN
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Maren Depke Results Host Cell Gene
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Maren Depke Results Pathogen Gene E
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S. aureus RN1HG sample conditions a
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mean normalized intensity mean norm
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mean normalized intensity Maren Dep
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log 2 (ratio) log 2 (ratio) log 2 (
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Maren Depke D I S C U S S I O N A N
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Maren Depke Discussion and Conclusi
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Maren Depke References Athanasopoul
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Maren Depke References Byrne GI, Le
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Maren Depke References Demling R. T
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Maren Depke References Foss GS, Pry
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Maren Depke References Hagopian K,
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Maren Depke References Jin T, Bokar
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Maren Depke References Kwan T, Liu
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Maren Depke References Luster AD, U
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Maren Depke References Namiki S, Na
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Maren Depke References Puccetti P.
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Maren Depke References Siewert E, B
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Maren Depke References van den Akke
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Maren Depke References Yang XL, Sch
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Maren Depke A F F I D A V I T / E R
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Maren Depke Acknowledgments Kidney
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