genomewide characterization of host-pathogen interactions by ...
genomewide characterization of host-pathogen interactions by ...
genomewide characterization of host-pathogen interactions by ...
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Maren Depke<br />
Results<br />
Pathogen Gene Expression Pr<strong>of</strong>iling<br />
C<br />
peptidoglycan<br />
biosynthesis<br />
fructose, glycine betaine<br />
permease/transporter<br />
different<br />
fermentation<br />
pathways<br />
acetoin<br />
biosynthesis<br />
degradation <strong>of</strong> glycerol, mannitol,<br />
galactose, fructose, nucleosides,<br />
citrulline/ornithine, arg, his, ala<br />
and others<br />
ammonium transporter<br />
gluconeogenesis<br />
uracil<br />
permease<br />
oligopeptide<br />
transporters<br />
spermidine/<br />
putrescine<br />
transporter<br />
protease<br />
proline betaine transporter<br />
branched and standard<br />
amino acid transporter<br />
phospho-transferase system<br />
(PTS); glucose-and mannitolspecific<br />
components<br />
purine and<br />
pyrimidine<br />
nucleotide<br />
biosynthesis<br />
glycolysis<br />
fatty acid<br />
biosynthesis<br />
amino acid<br />
biosynthesis<br />
sodium<br />
glutamate<br />
symporter<br />
proline uptake protein<br />
tRNA charging<br />
pathways<br />
anaerobic<br />
respiration<br />
aerobic<br />
respiration<br />
protein modification: oxoacylreductase,<br />
ketoacyl-reductase,<br />
oxoacyl-synthase reactions at<br />
different C positions<br />
D<br />
fructose, glycine betaine, choline,<br />
transporter/permease<br />
Na + /H + antiporter<br />
Mo 2+ transporter<br />
different<br />
fermentation<br />
pathways<br />
acetoin<br />
biosynthesis<br />
degradation <strong>of</strong> glycerol, mannitol,<br />
galactose, fructose, nucleosides,<br />
citrulline/ornithine, arg, his, ala<br />
and others<br />
S-, L-lactate permease<br />
proline betaine transporter<br />
monovalent<br />
cation/proton<br />
antiporter<br />
oligopeptide<br />
transporter<br />
ferrichrome<br />
transport<br />
permease;<br />
monovalent<br />
cation/proton<br />
antiporter;<br />
spermidine/<br />
putrescine<br />
transporter<br />
fatty acid<br />
biosynthesis<br />
arginine/<br />
ornithine<br />
antiporter<br />
amino acid<br />
biosynthesis<br />
nickel permease,<br />
Na + /H + antiporter<br />
sodium/glutamate symporter<br />
proline uptake protein<br />
tRNA charging<br />
pathways<br />
Na + /H + antiporter<br />
ferrichrome ABC<br />
transporter<br />
branched amino acid<br />
transporter<br />
standard amino acid<br />
transporter<br />
phospho-transferase system<br />
(PTS); glucose-and mannitolspecific<br />
components<br />
protein modification: oxoacylreductase,<br />
ketoacyl-reductase,<br />
oxoacyl-synthase reactions at<br />
different C positions<br />
Fig. R.5.23: The influence <strong>of</strong> internalization and control treatment on gene expression in staphylococcal NCTC8325 metabolic<br />
pathways (modified from omics-viewer(s) <strong>of</strong> BIOCYC, SRI International, CA, USA, http://biocyc.org/expression.html).<br />
Nodes represent metabolites, and lines indicate reactions. The metabolic reactions are colored according to the enzymes’ gene<br />
expression regulation in the samples <strong>of</strong> 2.5 h internalization (A), 6.5 h internalization (B), 2.5 h serum/CO 2 control (C), and 2.5 h<br />
anaerobic incubation; each sample was compared versus the baseline <strong>of</strong> 1 h serum/CO 2 control. Red marks an increase and yellow a<br />
decrease <strong>of</strong> expression in the sample. The display is limited to genes which were significant with p* < 0.05 in statistical testing and<br />
whose mean absolute fold change exceeded 2.<br />
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