genomewide characterization of host-pathogen interactions by ...

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Maren Depke Results Pathogen Gene Expression Profiling A phosphonate/ phosphate transporters uracil permease oligopeptide transporters spermidine/ putrescine transporter purine and pyrimidine nucleotide biosynthesis sodium/sulfate, fructose, glycine betaine, choline, L-lactate, xanthine, urea transporter/symporter/permease acetoin biosynthesis different fermentation pathways degradation of glycerol, mannitol, galactose, fructose, nucleosides, citrulline/ornithine, arg, his, ala and others maltose transporter protease proline betaine transporter amino acid transporter phospho-transferase system (PTS); glucose-and mannitolspecific components glycolysis fatty acid biosynthesis arginine/ ornithine antiporter amino acid biosynthesis sodium-dependent tr., phosphate transporter sodium/glutamate symporter, proline uptake protein, citrate transporter tRNA charging pathways anaerobic respiration aerobic respiration gluconate permease protein modification: oxoacylreductase, ketoacyl-reductase, oxoacyl-synthase reactions at different C positions B choline, L-lactate transporter different fermentation pathways acetoin biosynthesis degradation of glycerol, mannitol, galactose, fructose, nucleosides, citrulline/ornithine, arg, his, ala and others protease phosponate/ phosphate and oligopeptide transporters spermidine/ putrescine transporter proline betaine transporter amino acid transporter phospho-transferase system (PTS); glucose-and mannitolspecific components purine and pyrimidine nucleotide biosynthesis glycolysis fatty acid biosynthesis arginine/ ornithine antiporter amino acid biosynthesis phosphate transporter tRNA charging sodium/glutamate symporter pathways proline uptake protein anaerobic respiration aerobic respiration gluconate permease protein modification: oxoacylreductase, ketoacyl-reductase, oxoacyl-synthase reactions at different C positions 156
Maren Depke Results Pathogen Gene Expression Profiling C peptidoglycan biosynthesis fructose, glycine betaine permease/transporter different fermentation pathways acetoin biosynthesis degradation of glycerol, mannitol, galactose, fructose, nucleosides, citrulline/ornithine, arg, his, ala and others ammonium transporter gluconeogenesis uracil permease oligopeptide transporters spermidine/ putrescine transporter protease proline betaine transporter branched and standard amino acid transporter phospho-transferase system (PTS); glucose-and mannitolspecific components purine and pyrimidine nucleotide biosynthesis glycolysis fatty acid biosynthesis amino acid biosynthesis sodium glutamate symporter proline uptake protein tRNA charging pathways anaerobic respiration aerobic respiration protein modification: oxoacylreductase, ketoacyl-reductase, oxoacyl-synthase reactions at different C positions D fructose, glycine betaine, choline, transporter/permease Na + /H + antiporter Mo 2+ transporter different fermentation pathways acetoin biosynthesis degradation of glycerol, mannitol, galactose, fructose, nucleosides, citrulline/ornithine, arg, his, ala and others S-, L-lactate permease proline betaine transporter monovalent cation/proton antiporter oligopeptide transporter ferrichrome transport permease; monovalent cation/proton antiporter; spermidine/ putrescine transporter fatty acid biosynthesis arginine/ ornithine antiporter amino acid biosynthesis nickel permease, Na + /H + antiporter sodium/glutamate symporter proline uptake protein tRNA charging pathways Na + /H + antiporter ferrichrome ABC transporter branched amino acid transporter standard amino acid transporter phospho-transferase system (PTS); glucose-and mannitolspecific components protein modification: oxoacylreductase, ketoacyl-reductase, oxoacyl-synthase reactions at different C positions Fig. R.5.23: The influence of internalization and control treatment on gene expression in staphylococcal NCTC8325 metabolic pathways (modified from omics-viewer(s) of BIOCYC, SRI International, CA, USA, http://biocyc.org/expression.html). Nodes represent metabolites, and lines indicate reactions. The metabolic reactions are colored according to the enzymes’ gene expression regulation in the samples of 2.5 h internalization (A), 6.5 h internalization (B), 2.5 h serum/CO 2 control (C), and 2.5 h anaerobic incubation; each sample was compared versus the baseline of 1 h serum/CO 2 control. Red marks an increase and yellow a decrease of expression in the sample. The display is limited to genes which were significant with p* < 0.05 in statistical testing and whose mean absolute fold change exceeded 2. 157
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G E N O M E W I D E C H A R A C T E
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Maren Depke C O N T E N T S GENOMEW
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Maren Depke Z U S A M M E N F A S S
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Maren Depke Zusammenfassung der Dis
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Maren Depke S U M M A R Y O F D I S
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Maren Depke Summary of Dissertation
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Maren Depke I N T R O D U C T I O N
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Maren Depke Introduction Besides op
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Maren Depke Introduction Extracellu
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Maren Depke Introduction with heigh
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Maren Depke Introduction 2005). SaP
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Maren Depke Introduction contains a
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Maren Depke Introduction via fibron
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Maren Depke Introduction cathelicid
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Maren Depke Introduction shock are
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Maren Depke Introduction STUDIES OF
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Maren Depke Introduction are effect
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Maren Depke Introduction cell stimu
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Maren Depke Introduction channel CF
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Maren Depke M A T E R I A L A N D M
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Maren Depke Material and Methods Li
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Maren Depke Material and Methods Ki
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Maren Depke Material and Methods GE
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Maren Depke Material and Methods Ge
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Ho
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Maren Depke Material and Methods Pa
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corticosterone [pg/ml plasma] corti
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Maren Depke Results Liver Gene Expr
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lood glucose levels [nmol/l] resist
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LBP [ng/ml] CPR [ng/ml] Maren Depke
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Maren Depke Results Liver Gene Expr
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liver weight [g] Maren Depke Result
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infection rate cfu / 10 mg tissue c
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Maren Depke Results Kidney Gene Exp
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Table R.2.1: Genes displaying stati
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Maren Depke BR1 sign DsigB vs wt BR
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Maren Depke Results GENE EXPRESSION
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Maren Depke Results Gene Expression
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log2(ratio C57BL/6 / BALB/c) at IFN
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Page 105 and 106: Maren Depke Results Gene Expression
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Maren Depke References Athanasopoul
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Maren Depke References Byrne GI, Le
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Maren Depke References Demling R. T
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Maren Depke References Foss GS, Pry
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Maren Depke References Hagopian K,
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Maren Depke References Jin T, Bokar
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Maren Depke References Kwan T, Liu
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Maren Depke References Luster AD, U
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Maren Depke References Namiki S, Na
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Maren Depke References Puccetti P.
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Maren Depke References Siewert E, B
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Maren Depke References van den Akke
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Maren Depke References Yang XL, Sch
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Maren Depke A F F I D A V I T / E R
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Maren Depke Acknowledgments Kidney
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