genomewide characterization of host-pathogen interactions by ...
genomewide characterization of host-pathogen interactions by ...
genomewide characterization of host-pathogen interactions by ...
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Maren Depke<br />
Results<br />
Host Cell Gene Expression Pattern in an in vitro Infection Model<br />
repressed (CDH10, −1.9). Increased expression was also observed for adhesion molecules ALCAM<br />
(1.8) and CEACAM1 (9.9). ALCAM was one <strong>of</strong> the genes whose protein abundance change was in<br />
accordance with the differential expression (Table R.4.10, Table R.4.3).<br />
Table R.4.10: Overview on selected differentially expressed cell adhesion related genes in S9 cells 6.5 h after start <strong>of</strong> infection with<br />
S. aureus RN1HG GFP.<br />
gene<br />
name<br />
description<br />
Rosetta Resolver annotation<br />
Entrez<br />
Gene<br />
ID<br />
alias<br />
fold change a<br />
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit <strong>of</strong> VLA-2 receptor) 3673 BR, GPIa, CD49B,VLA-2 2.9<br />
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 3678 FNRA, CD49e,VLA5A 2.0<br />
ITGA11 integrin, alpha 11 22801 1.6<br />
ITGB8 integrin, beta 8 3696 ITGB8 2.6<br />
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 26548 CHORDC3, ITGB1BP 1.8<br />
CYTH1 cytohesin 1 9267 B2-1,SEC7,PSCD1 2.1<br />
PCDH7 protocadherin 7 5099 BHPCDH 4.1<br />
PCDH17 protocadherin 17 27253 PCH68, PCDH68 2.1<br />
CDH8 cadherin 8, type 2 1006 1.6<br />
CDH10 cadherin 10, type 2 (T2-cadherin) 1008 -1.9<br />
ALCAM activated leukocyte cell adhesion molecule 214 MEMD, CD166 1.8<br />
CEACAM1<br />
carcinoembryonic antigen-related cell adhesion molecule 1<br />
(biliary glycoprotein)<br />
634 BGP, BGP1, BGPI 9.9<br />
a Fold change values were calculated for the comparison <strong>of</strong> infected GFP + S9 cell with the baseline <strong>of</strong> medium control samples.<br />
6.5 h<br />
130