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INVESTIGATIONS INTO HYPERLIPIDEMIA
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INVESTIGATIONS INTO HYPERLIPIDEMIA
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iv was found to be useful for the s
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vi ACKNOWLEDGEMENTS I would like to
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viii TABLE OF CONTENTS Page ABSTRAC
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x LIST OF FIGURES FIGURE Page 1 Cor
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xii FIGURE Page 20 1-dimensional sl
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2 the results of these initial stud
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4 and HDL 1 concentrations and a de
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6 and, in smaller concentrations, L
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8 HDL molecules can be further subd
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10 reach the vasculature, they acqu
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12 Endocrine disease Most commonly,
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14 with varying frequencies in dogs
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16 hypercholesterolemia was found o
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18 Primary hyperlipidemia with hype
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20 Atherosclerosis Although dogs ap
- Page 35 and 36: 22 Dietary management Typically, th
- Page 37 and 38: 24 therapy when the latter fails to
- Page 39 and 40: 26 followed from the 1970s until to
- Page 41 and 42: 28 this theory, zymogen granules th
- Page 43 and 44: 30 be quite different, especially i
- Page 45 and 46: 32 Drugs As in humans, drug-induced
- Page 47 and 48: 34 Signalment Dogs of any age, bree
- Page 49 and 50: 36 erroneously direct the clinician
- Page 51 and 52: 38 of changes over time in serum Sp
- Page 53 and 54: 40 they have been shown to have a l
- Page 55 and 56: 42 revealed either a normal pancrea
- Page 57 and 58: 44 At present, a definitive diagnos
- Page 59 and 60: 46 factors should always be investi
- Page 61 and 62: 48 associated pancreatitis is much
- Page 63 and 64: 50 clear whether hyperlipidemia was
- Page 65 and 66: 52 hepatobiliary disease in both Mi
- Page 67 and 68: 54 the reference range, while Group
- Page 69 and 70: 56 ROC analysis and calculation of
- Page 71 and 72: 58 Figure 3. Serum cPLI concentrati
- Page 73 and 74: 60 There was no significant differe
- Page 75 and 76: 62 severe (typically ≥1,000 mg/dl
- Page 77 and 78: 64 gastrointestinal signs or suspec
- Page 79 and 80: 66 CHAPTER III SERUM TRIGLYCERIDE C
- Page 81 and 82: 68 logical assumption that a defect
- Page 83 and 84: 70 pancreatitis. For the same reaso
- Page 85: 72 Spec cPL concentrations were mea
- Page 89 and 90: 76 Figure 5. Comparison of serum tr
- Page 91 and 92: 78 Figure 7. Comparison of serum tr
- Page 93: 80 pancreatitis as it cannot be pre
- Page 96 and 97: 83 Although serum cholesterol conce
- Page 98 and 99: 85 Footnotes a Spec cPL ® , IDEXX
- Page 100 and 101: 87 several subfractions, with diffe
- Page 102 and 103: 89 Miniature Schnauzers (Group 2) T
- Page 104 and 105: 91 Assays Serum triglyceride (refer
- Page 106 and 107: 93 Figure 8. Custom-built fluoresce
- Page 108 and 109: 95 range HDL 1 has not been accurat
- Page 110 and 111: 97 mg/dL) were significantly higher
- Page 112 and 113: 99 Figure 10: Serum cholesterol con
- Page 114 and 115: 101 (Eigenvalues=0.5455; P=0.00017;
- Page 116 and 117: 103 Figure 12: Representative lipop
- Page 118 and 119: 105 Figures 14A and 14B: Representa
- Page 120 and 121: 107 Specifically, 97% of non-hypert
- Page 122 and 123: 109 The fraction of TRLs was a sign
- Page 124 and 125: 111 Schnauzers without hyperlipidem
- Page 126 and 127: 113 Footnotes a Roche/Hitachi MODUL
- Page 128 and 129: 115 The biochemical, metabolic, and
- Page 130 and 131: 117 Study design Each one of the do
- Page 132 and 133: 119 Questionnaires and consent form
- Page 134 and 135: 121 a target intensity of 30%, and
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123 might affect lipid metabolism (
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125 Figure 16. Serum triglyceride c
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127 Figure 18. Serum Spec cPL conce
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129 Figure 19. 1-dimensional sliced
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131 Dogs that did not respond to th
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133 Hypertriglyceridemia has been l
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135 degrees. One possible explanati
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137 Footnotes a Royal Canin Gastroi
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139 concentrations and lipoprotein
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141 inclusion criteria for the stud
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143 light source j , located in a d
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146 Serum triglyceride and choleste
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148 Figure 22. Serum triglyceride c
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150 Figure 24. 1-dimensional sliced
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152 Discussion The purpose of the p
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154 fraction of these dogs (about 3
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156 of lipoproteins might also have
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158 Footnotes a Roche/Hitachi MODUL
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160 the etiology of pancreatitis, b
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162 times (P=0.0343) for a serum cP
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164 peaks than dogs of other breeds
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166 19.3; 95% CI, 2.0-184.0; P=0.00
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168 4) Specific lipoprotein classes
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170 REFERENCES 1949;8:96-97. 1. Lew
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172 17. Whitney MS, Boon GD, Rebar
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174 33. Ford RB. Clinical managemen
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176 50. Nelson RW, Turnwald GH, Wil
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178 66. Williams DA, Steiner JM. Ca
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180 82. Yilmaz Z, Senturk S. Charac
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182 97. Fojo SS, Stalenhoef AF, Mar
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184 111. Lam CW, Yuen YP, Cheng WF,
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186 127. Crispin SM. Ocular manifes
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188 144. Lindsay S, Entenmann C, Ch
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190 161. Steiner JM. Canine pancrea
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192 176. Steiner JM, Teague SR, Wil
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194 191. Steiner JM. Diagnosis of p
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196 208. Talukdar R, Vege S. Recent
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198 224. Koch K, Drewelow B, Liebe
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200 241. Petrov MS, van Santvoort H
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202 258. Ewald N, Hardt PD, Kloer H
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204 274. Otvos JD, Jeyarajah EJ, Be
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206 289. Carpentier YA, Scruel O. C