INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
61<br />
A serum triglyceride concentration of 862 mg/dL was selected based on ROC<br />
analysis, and this concentration was associated with a greater than 3-fold likelihood for<br />
having a serum cPLI concentration that is considered consistent with pancreatitis<br />
compared to the likelihood for dogs with triglyceride concentrations ≤ 862 mg/dL. The<br />
likelihood ratio for having a serum cPLI concentration that is consistent with pancreatitis<br />
was often higher (up to 8.5) when higher serum triglyceride concentrations were selected<br />
(Figure 2). Increases of serum triglyceride concentrations ≥ 862 mg/dL are generally<br />
considered to be rather severe. Results of the present study suggest that the severity of<br />
hypertriglyceridemia is an important factor affecting the risk for increased cPLI<br />
concentration consistent with pancreatitis in Miniature Schnauzers, and that only<br />
severely increased serum triglyceride concentrations are associated with an increased<br />
risk for an increased cPLI concentration consistent with pancreatitis in this breed. Mildly<br />
or moderately elevated serum triglyceride concentrations (e.g., < 800 mg/dL) did not<br />
appear to represent a risk factor for a serum cPLI concentration suggestive of<br />
pancreatitis in this study. These findings are in agreement with studies in humans, in<br />
which only severe hypertriglyceridemia is recognized as a cause of pancreatitis. 254,255 In<br />
humans, it has been reported that a serum triglyceride concentration above 1,000 mg/dL<br />
is an identifiable risk factor for pancreatitis. 255<br />
In human patients, it has been described that hypertriglyceridemia can either be<br />
the cause or the result of pancreatitis, and the same has also been suggested for<br />
dogs. 19,165,255 When hypertriglyceridemia is the result of pancreatitis in humans it is<br />
usually mild to moderate, while hypertriglyceridemia that causes pancreatitis is usually