INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...

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There was no significant difference in the proportion of dogs with serum cPLI
concentrations consistent with pancreatitis between dogs with hypertriglyceridemia (29
of 87 dogs; 33.3%) and dogs with normal triglyceride concentrations (21 of 75 dogs;
28%; P=0.4986). However, of the 87 dogs with hypertriglyceridemia, 11 had serum
triglyceride concentrations ≥862 mg/dL, and there was a statistically significant
difference in the proportion of dogs with serum cPLI concentrations consistent with
pancreatitis between the dogs with serum triglyceride concentrations ≥862 mg/dL (7 of
11 dogs; 63.6%) and dogs with serum triglyceride concentrations in the reference range
(21 of 75 dogs; 28%; P=0.0343; odds ratio, 4.5; 95% CI, 1.2 to 17.0).
Discussion
Results of the present study suggest an association between serum triglyceride
and cPLI concentrations in Miniature Schnauzers. Miniature Schnauzers with
hypertriglyceridemia were found to have significantly higher serum cPLI concentrations
than Miniature Schnauzers with normal serum triglyceride concentrations. In addition,
Miniature Schnauzers with serum triglyceride concentrations ≥862 mg/dl were 4.5 times
(95% CI, 1.2 to 17.0) more likely to have serum cPLI concentrations considered
consistent with pancreatitis (>200 μg/L) than Miniature Schnauzers with normal serum
triglyceride concentrations. Although previous studies have shown a frequent coexistence
of hypertriglyceridemia and pancreatitis in dogs, the present study is the first
to implicate the degree of hypertriglyceridemia as a cause of increased serum cPLI
concentrations consistent with pancreatitis in Miniature Schnauzers. 19,63,65