INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
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60<br />
There was no significant difference in the proportion of dogs with serum cPLI<br />
concentrations consistent with pancreatitis between dogs with hypertriglyceridemia (29<br />
of 87 dogs; 33.3%) and dogs with normal triglyceride concentrations (21 of 75 dogs;<br />
28%; P=0.4986). However, of the 87 dogs with hypertriglyceridemia, 11 had serum<br />
triglyceride concentrations ≥862 mg/dL, and there was a statistically significant<br />
difference in the proportion of dogs with serum cPLI concentrations consistent with<br />
pancreatitis between the dogs with serum triglyceride concentrations ≥862 mg/dL (7 of<br />
11 dogs; 63.6%) and dogs with serum triglyceride concentrations in the reference range<br />
(21 of 75 dogs; 28%; P=0.0343; odds ratio, 4.5; 95% CI, 1.2 to 17.0).<br />
Discussion<br />
Results of the present study suggest an association between serum triglyceride<br />
and cPLI concentrations in Miniature Schnauzers. Miniature Schnauzers with<br />
hypertriglyceridemia were found to have significantly higher serum cPLI concentrations<br />
than Miniature Schnauzers with normal serum triglyceride concentrations. In addition,<br />
Miniature Schnauzers with serum triglyceride concentrations ≥862 mg/dl were 4.5 times<br />
(95% CI, 1.2 to 17.0) more likely to have serum cPLI concentrations considered<br />
consistent with pancreatitis (>200 μg/L) than Miniature Schnauzers with normal serum<br />
triglyceride concentrations. Although previous studies have shown a frequent coexistence<br />
of hypertriglyceridemia and pancreatitis in dogs, the present study is the first<br />
to implicate the degree of hypertriglyceridemia as a cause of increased serum cPLI<br />
concentrations consistent with pancreatitis in Miniature Schnauzers. 19,63,65