INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
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37<br />
assay was reported at 78%. 180<br />
Experimentally induced chronic renal failure and<br />
prednisone administration were not found to have a clinically significant effect on serum<br />
cPLI concentration. 181,182<br />
The specificity of cPLI needs further investigation in dogs<br />
with various gastrointestinal diseases but no pancreatitis. It also remains to be<br />
determined whether serum cPLI concentration can be increased in patients with<br />
histopathologically mild pancreatitis that might be of minor clinical importance and does<br />
not contribute to the development of clinical signs. Overall, compared to other serum<br />
tests currently available, serum cPLI is considered to have the highest specificity for<br />
pancreatitis. 179-185<br />
Studies also show that serum cPLI concentration is sensitive for the diagnosis of<br />
pancreatitis in dogs. 177,180,186,187 The reported sensitivity of cPLI for the diagnosis of<br />
canine pancreatitis ranges between 64% and 93%, possibly depending on the severity of<br />
the disease in the patients studied. Overall, the sensitivity of serum cPLI is higher than<br />
any other serum test currently available. 177,180,186,187 However, false negative results are<br />
likely to occur especially in mild cases.<br />
Overall, serum cPLI concentration appears to be a sensitive and specific marker<br />
of canine pancreatitis, and is currently considered to be the serum test of choice for the<br />
diagnosis of pancreatitis in this species.<br />
Based on clinical observations and the results of studies available to date, 177<br />
serum cPLI concentration does not appear to correlate with the severity of pancreatitis.<br />
Therefore, an individual measurement of serum cPLI concentration cannot be used to<br />
predict the severity of pancreatitis. No controlled studies have looked at the significance