INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
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31<br />
the mutant protein lacks this function, thereby leaving the acinar cell more susceptible to<br />
injury, although this has not been convincingly shown in either humans or dogs. Thus,<br />
the exact role of variants of the SPINK1 gene in the development of pancreatitis in<br />
Miniature Schnauzers remains to be determined. It has been hypothesized that mutations<br />
of this gene may not actually cause pancreatitis, but may sensitize the pancreas to injury<br />
through other factors. Based on the fact that some breeds have been found to be<br />
overrepresented in some reports, genetic causes of pancreatitis have also been suspected<br />
in other breeds (e.g., Yorkshire Terriers). 64<br />
Diet<br />
The role of diet, and more specifically the fat content of the diet, in the<br />
development of canine pancreatitis remains largely unclear. Based on anecdotal clinical<br />
observations, foods high in fat increase the risk of pancreatitis. Older experimental<br />
studies have suggested that diets with a very high fat content may induce pancreatitis<br />
and may increase the severity of experimentally induced pancreatitis in dogs. 144,165 The<br />
mechanism by which high-fat diets increase the risk for pancreatitis is not known, but it<br />
is possible that high-fat diets may predispose dogs to pancreatitis through<br />
hypertriglyceridemia as a result of a fatty meal. In a recent retrospective case-control<br />
study of dogs, several factors such as getting into the trash, consuming table scraps, and<br />
ingestion of “unusual” food were found to be associated with increased odds of<br />
pancreatitis. 163 However, no specific foods were identified that could be associated with<br />
an increased risk of pancreatitis.