- Page 1 and 2: INVESTIGATIONS INTO HYPERLIPIDEMIA
- Page 3 and 4: INVESTIGATIONS INTO HYPERLIPIDEMIA
- Page 5 and 6: iv was found to be useful for the s
- Page 7 and 8: vi ACKNOWLEDGEMENTS I would like to
- Page 9 and 10: viii TABLE OF CONTENTS Page ABSTRAC
- Page 11 and 12: x LIST OF FIGURES FIGURE Page 1 Cor
- Page 13 and 14: xii FIGURE Page 20 1-dimensional sl
- Page 15 and 16: 2 the results of these initial stud
- Page 17 and 18: 4 and HDL 1 concentrations and a de
- Page 19 and 20: 6 and, in smaller concentrations, L
- Page 21 and 22: 8 HDL molecules can be further subd
- Page 23 and 24: 10 reach the vasculature, they acqu
- Page 25 and 26: 12 Endocrine disease Most commonly,
- Page 27 and 28: 14 with varying frequencies in dogs
- Page 29 and 30: 16 hypercholesterolemia was found o
- Page 31 and 32: 18 Primary hyperlipidemia with hype
- Page 33 and 34: 20 Atherosclerosis Although dogs ap
- Page 35: 22 Dietary management Typically, th
- Page 39 and 40: 26 followed from the 1970s until to
- Page 41 and 42: 28 this theory, zymogen granules th
- Page 43 and 44: 30 be quite different, especially i
- Page 45 and 46: 32 Drugs As in humans, drug-induced
- Page 47 and 48: 34 Signalment Dogs of any age, bree
- Page 49 and 50: 36 erroneously direct the clinician
- Page 51 and 52: 38 of changes over time in serum Sp
- Page 53 and 54: 40 they have been shown to have a l
- Page 55 and 56: 42 revealed either a normal pancrea
- Page 57 and 58: 44 At present, a definitive diagnos
- Page 59 and 60: 46 factors should always be investi
- Page 61 and 62: 48 associated pancreatitis is much
- Page 63 and 64: 50 clear whether hyperlipidemia was
- Page 65 and 66: 52 hepatobiliary disease in both Mi
- Page 67 and 68: 54 the reference range, while Group
- Page 69 and 70: 56 ROC analysis and calculation of
- Page 71 and 72: 58 Figure 3. Serum cPLI concentrati
- Page 73 and 74: 60 There was no significant differe
- Page 75 and 76: 62 severe (typically ≥1,000 mg/dl
- Page 77 and 78: 64 gastrointestinal signs or suspec
- Page 79 and 80: 66 CHAPTER III SERUM TRIGLYCERIDE C
- Page 81 and 82: 68 logical assumption that a defect
- Page 83 and 84: 70 pancreatitis. For the same reaso
- Page 85 and 86: 72 Spec cPL concentrations were mea
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74 were significantly more likely t
- Page 89 and 90:
76 Figure 5. Comparison of serum tr
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78 Figure 7. Comparison of serum tr
- Page 93:
80 pancreatitis as it cannot be pre
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83 Although serum cholesterol conce
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85 Footnotes a Spec cPL ® , IDEXX
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87 several subfractions, with diffe
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89 Miniature Schnauzers (Group 2) T
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91 Assays Serum triglyceride (refer
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93 Figure 8. Custom-built fluoresce
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95 range HDL 1 has not been accurat
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97 mg/dL) were significantly higher
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99 Figure 10: Serum cholesterol con
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101 (Eigenvalues=0.5455; P=0.00017;
- Page 116 and 117:
103 Figure 12: Representative lipop
- Page 118 and 119:
105 Figures 14A and 14B: Representa
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107 Specifically, 97% of non-hypert
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109 The fraction of TRLs was a sign
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111 Schnauzers without hyperlipidem
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113 Footnotes a Roche/Hitachi MODUL
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115 The biochemical, metabolic, and
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117 Study design Each one of the do
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119 Questionnaires and consent form
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121 a target intensity of 30%, and
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123 might affect lipid metabolism (
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125 Figure 16. Serum triglyceride c
- Page 140 and 141:
127 Figure 18. Serum Spec cPL conce
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129 Figure 19. 1-dimensional sliced
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131 Dogs that did not respond to th
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133 Hypertriglyceridemia has been l
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135 degrees. One possible explanati
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137 Footnotes a Royal Canin Gastroi
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139 concentrations and lipoprotein
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141 inclusion criteria for the stud
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143 light source j , located in a d
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146 Serum triglyceride and choleste
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148 Figure 22. Serum triglyceride c
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150 Figure 24. 1-dimensional sliced
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152 Discussion The purpose of the p
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154 fraction of these dogs (about 3
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156 of lipoproteins might also have
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158 Footnotes a Roche/Hitachi MODUL
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160 the etiology of pancreatitis, b
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162 times (P=0.0343) for a serum cP
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164 peaks than dogs of other breeds
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166 19.3; 95% CI, 2.0-184.0; P=0.00
- Page 181 and 182:
168 4) Specific lipoprotein classes
- Page 183 and 184:
170 REFERENCES 1949;8:96-97. 1. Lew
- Page 185 and 186:
172 17. Whitney MS, Boon GD, Rebar
- Page 187 and 188:
174 33. Ford RB. Clinical managemen
- Page 189 and 190:
176 50. Nelson RW, Turnwald GH, Wil
- Page 191 and 192:
178 66. Williams DA, Steiner JM. Ca
- Page 193 and 194:
180 82. Yilmaz Z, Senturk S. Charac
- Page 195 and 196:
182 97. Fojo SS, Stalenhoef AF, Mar
- Page 197 and 198:
184 111. Lam CW, Yuen YP, Cheng WF,
- Page 199 and 200:
186 127. Crispin SM. Ocular manifes
- Page 201 and 202:
188 144. Lindsay S, Entenmann C, Ch
- Page 203 and 204:
190 161. Steiner JM. Canine pancrea
- Page 205 and 206:
192 176. Steiner JM, Teague SR, Wil
- Page 207 and 208:
194 191. Steiner JM. Diagnosis of p
- Page 209 and 210:
196 208. Talukdar R, Vege S. Recent
- Page 211 and 212:
198 224. Koch K, Drewelow B, Liebe
- Page 213 and 214:
200 241. Petrov MS, van Santvoort H
- Page 215 and 216:
202 258. Ewald N, Hardt PD, Kloer H
- Page 217 and 218:
204 274. Otvos JD, Jeyarajah EJ, Be
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206 289. Carpentier YA, Scruel O. C