INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...

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with varying frequencies in dogs with acquired glomerular disease and proteinuria, as
well as in several hereditary forms of PLN (e.g., in Chinese Shar-Peis and Golden
Retrievers). 69-73
Cholestasis
Cholestasis has been reported to lead to mild or moderate hypercholesterolemia
and mild hypertriglyceridemia in dogs. 49,74,75 Changes in lipoproteins, most importantly
excessive esterification of lipoprotein cholesterol, have also been reported in dogs with
experimentally induced cholestasis. 76,77
Other causes
Several other causes of hyperlipidemia have been reported or suspected in dogs.
These include high fat diets, lymphoma, infection with Leishmania infantum, congestive
heart failure due to dilated cardiomyopathy, and administration of certain drugs (e.g.,
glucocorticoids, estrogen, phenobarbital, and potassium bromide). 14,78-81 Finally, in a
recent study, significantly increased serum triglyceride concentrations were reported in
association with other lipid abnormalities in dogs with parvoviral enteritis. 82
Primary causes of hyperlipidemia in dogs
Primary lipid abnormalities are usually, but not always, associated with specific
breeds. Depending on the breed, the prevalence of primary lipid abnormalities can vary
widely.