INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...

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in Miniature Schnauzers with a recent history of pancreatitis to those without a history of
pancreatitis, 3) to evaluate the feasibility and assess the usefulness of a novel method for
ultracentrifugal separation of lipoproteins as a means for lipoprotein fingerprinting in
dogs, 4) to compare the lipoprotein profiles among dogs of various breeds, healthy
Miniature Schnauzers, and Miniature Schnauzers with hyperlipidemia, 5) to evaluate the
effect of a commercially available ultra-low-fat diet on serum triglyceride, cholesterol,
and Spec cPL concentrations, as well as the lipoprotein profiles, in Miniature Schnauzers
with suspected primary hypertriglyceridemia, and 6) to evaluate serum triglyceride and
cholesterol concentrations and describe the lipoprotein profiles in dogs with and without
pancreatitis.
In the first part of the study, the objective was to investigate a possible
association between serum triglyceride and canine pancreatic lipase immunoreactivity
(cPLI) concentrations in Miniature Schnauzers. One hundred and ninety-five Miniature
Schnauzers were enrolled and divided into 2 groups based on whether they had normal
(Group 1) or increased (Group 2) serum triglyceride concentrations. Serum triglyceride
and cPLI concentrations were measured and compared between groups. There was a
significant but weak positive correlation between serum triglyceride and cPLI
concentrations (r=0.321; P