INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
INVESTIGATIONS INTO HYPERLIPIDEMIA AND ITS POSSIBLE ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
155<br />
Both LDL and HDL fractions contain mainly cholesterol. 252 The fact that the overall<br />
serum cholesterol concentration was normal in the majority of dogs with pancreatitis<br />
might be explained by the fact that increases in LDL fractions were balanced by a<br />
concurrent decrease in the HDL fractions. It is possible that during pancreatitis<br />
lipoprotein metabolism is altered in a way that facilitates redistribution of lipid<br />
components (mainly cholesterol) between LDL and HDL fractions. Further studies are<br />
needed to elucidate the mechanism of lipoprotein metabolism alterations in dogs with<br />
pancreatitis.<br />
The changes in lipoprotein profiles in dogs with pancreatitis described in the<br />
present study are in agreement with the findings of studies on experimentally induced<br />
pancreatitis in dogs. 18-20<br />
Those studies have all reported similar findings, including<br />
increases in LDL and decreases in HDL fractions. Based on these findings, serum<br />
alterations in the major lipoprotein fractions are similar between naturally occurring and<br />
experimentally induced pancreatitis. However, changes in lipoprotein subfractions as a<br />
result of experimental pancreatitis have not been reported in other studies and<br />
differences might be present.<br />
TRLs were overall decreased in dogs with pancreatitis in the present study. To<br />
the authors’ knowledge, this has not been described before in dogs with pancreatitis<br />
without concurrent diseases affecting the lipoprotein metabolism. Since TRL are the<br />
main lipoprotein fractions containing triglycerides, this finding contradicts another<br />
finding of the present study, which showed that serum triglyceride concentrations were<br />
significantly higher in dogs with pancreatitis. This finding might suggest that the content