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il\VOLVEMENT OF RETII\OIC ACID II{
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Title: AKNOWLEDGMENTS DEDICATION LI
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IV.b.3. The uptake to peripheral ti
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II.a. Total RAR and total RXR recep
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ACKNO\ryLEDGMENTS I must say that m
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DEDICATION To my toughest critic, m
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Figure: LIST OF FIGURES Page: 1. Ch
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30. A and B The expression of anti-
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treated (ADR), trolox treated (TROL
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INTRODUCTION Adriamycin, an anthrac
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apoptosis, which will ultimately pr
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LITERATURE REVIE\il I. Adriamycin i
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Binding and alkylation of DNA Inter
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myocardial inflammation which was s
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1990; Kusuoka et al. l99l; Olson et
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levels of antioxidant enzymes (Odom
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causing the increased leakage of el
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mechanisms which are involved in th
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to protect against adriamycin-induc
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The usage of Probucol.' Most promis
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II. Oxidative stress II.a. Introduc
- Page 43 and 44: of a large array of cellular abnorm
- Page 45 and 46: menstruation (Kokawa et al. 1996),
- Page 47 and 48: DNA(Cohen 1997; Saikumar et al. 199
- Page 49 and 50: pathogenesis of heart failure. A nu
- Page 51 and 52: elonging to spontaneous hlpertensiv
- Page 53 and 54: AlþTrsns Retlnolc Acld fAfRAl g€
- Page 55 and 56: dehydrogenase (SDR), alcohol dehydr
- Page 57 and 58: (Bavik et a|. 1991). Soon after its
- Page 59 and 60: et al. 1994; Napoli 1996). The func
- Page 61: is achieved through its binding to
- Page 64 and 65: Retinoic acid signaling pathwaybegi
- Page 66 and 67: (Bavik et al. 1997). One of the mos
- Page 68 and 69: cells (Gaetano et ai. ZOot¡. The s
- Page 70 and 71: neuroblastoma, genn cell tumors and
- Page 72 and 73: presence of two distinctive pathway
- Page 74 and 75: cytochrome C release from mitochond
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- Page 78 and 79: adipose tissue and to a lesser exte
- Page 80 and 81: such as; increased generation of re
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- Page 84 and 85: Protective effects of PPAR y agonis
- Page 86 and 87: IIYPOTHESIS This study tests the hy
- Page 88 and 89: I.c.Collection of Tissues Hearts we
- Page 90 and 91: thoracotomy was performed and heart
- Page 92 and 93: Il.c.Western Blot Analvsis Western
- Page 96 and 97: RESULTS I.In Vivo Studies I.a.Gener
- Page 101: Lc. Retinoic acid receptors Three w
- Page 108: The RAR o and PPAR-õ receptors RNA
- Page 113 and 114: significantly decreased when compar
- Page 116: IL b.7. RAR alPha recePtor levels T
- Page 120: ILb. 3. RAR sammø recEtor levels F
- Page 124: ILb. 5. RXR baa recEúor levels The
- Page 129: visible staining were accounted as
- Page 137 and 138: DISSCUSION I. Adriamvcin CardiomvoP
- Page 139 and 140: Treatment with adriamycin has been
- Page 141 and 142: High RA 1 Adriamycin I oxidative st
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It is reported that PPAR y receptor
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expression. These effects of trolox
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REFERENCES Abdul Hamied,T.A., D.Par
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Bashor,M.M., D.O.Toft, and F.Chytll
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distribution of PPAR-alpha, -beta,
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colbert,M.C., D.G.Hall, T.R.Kimball
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Diep,Q.N., M'El Mabrouk, J.S.Cohn,
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Evans,R.M. 1988. "The steroid and t
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Ghione M. Development of Adriamycin
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Herman,E., R.Young, and S.Krop . Ig
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morphogenetic protein-2 inhibits se
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Khandoudi,N., P.Delerive, I.Berrebi
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Kusuoka,H., S.Futaki, Y.Koretsune,
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and myosin heavy chain gene express
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Mehta,J.L., B.Hu, J.Chen, and D.Li.
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Morriss-Kay,G.M. and s.J.ward. 1999
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Notario,B., M.Zamora, O.Vinas, and
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petkovich,M., N.J.Brand, A.Krust, a
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Ruberte,E., P.Dolle, P.Chambon, and
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Sharov,V.G., H.N.Sabbah, H.Shimoyam
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spiegelman,B.M. and J.s.Flier .1996
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Teebor,G.w., R.J.Boorstein, and J.c
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vanVeen,T.A.,H.V.vanRijen,R.F.V/ieg
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wi1liams,J.B. and J.L.Napoli. 1985.
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peroxisome proliferator-activated r