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II.b. 6. RXR s ømmn recePtor levels
Cells treated with 4 and 8 pM adriamycin did not exhibit any significant changes,
while the addition of 10 ¡rM adriamycin caused a significant decrease in the RXR gamma
levels (Fig.zÐ. The administration of trolox to 4 UM adriamycin treated myocytes had no
effect, but in the presence of 8 and 10 UlVf adriamycin, trolox administration resulted in
the 40Yo and,600/o decrease in the expression of RXR gamma (Fig.zÐ. The treatment with
0.1 trM retinoic acid caused a significant increase (200o/o, 150% and l40Yo) in the RXR
gaÍrma receptor levels at 4, I and 10 pM adriamycir¡ while I UM retinoic acid
administration to the adriamycin treated cells resulted in a small but significant decrease
in the expression of RXR gamma at all concentrations of the drug (Fig. 2a).
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