il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

ILb. 5. RXR baa recEúor levels
The administration of 8 and 10 UM of adriamycin to ADR treated cells caused
I03% and 147Yo increase in the expression of RXR beta (Fig. 23), while 4 pM
adriamycin had no effect on the expression of this receptor. The administration of trolox
to adriamycin treated cells caused a significant increase in RXR beta levels at all
concentrations of adriamycin (Fig. 23). The treatment with 0.1pM retinoic acid caused
75yo,70 Yo and 500á decrease in the RXR beta expression at 4, 8 and 10 pM adriamycin
respectively (Fig 23). Treatment with l¡rlVf retinoic acid resulted in significant increase
in the RXRbeta receptor levels at 8 and l0 pM adriamycin administration (Fig. 23).
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