il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

ILb.2. RARbetg receotor levels
The expression of RAR beta receptors was found tobe 60Yo increased in the 4 pM
adriamycin treated ADR group myocytes (Fig. 20). Alternatively, the treatment with I
and 10 FM concentration of adriamycin in the same group resulted in about a 45Yo
decrease in the RAR beta receptor levels (Fig. 20). The administration of antioxidant
trolox to 4 pM adriamycin treated cetls did not cause any significant change in the
expression of RAR beta, while a significant decrease was still apparent with I and 10 UM
adriamycin in the presence of trolox (Fig. 20). RAR P receptor levels were found to be
signifîcantly increased (98%) in 4 ¡rM adriamycin treated myocytes exposed to 0.1 pM
retinoic acid treatment. 0.1 pM retinoic acid treatment at 8 and 10 pM of adriamycin
caused a decrease in the RAR beta. Retinoic acid (lUM) administration caused a
signifîcant increase in RAR beta receptor levels at all concentrations of adriamycin (Fig'
20).
100