il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

did not cause in any significant change in the total RAR receptor levels when compared
to control, however these values were found to be 25o/o increased when compared to
ADR goup cells @ig. 16). The total RXR receptor levels were increased by I2Io/o when
compared with the ADR group (FiS. 17). These changes in the total RAR and RXR
receptor levels led to a signiflrcant increase (126%) in the RAR/RXR ratio (Fig. 18). The
administration of 0.1 UM retinoic acid to adriamycin-treated cells resulted in a 60Yo
decrease in the totat RAR receptor levels when compared to CONT (Fig. 16), but it did
not cause any changes in the total RXR receptor levels when compared to CONT (Fig.
17). These changes were reflected in the RAR/R)R ratio which was decreased to about
75Yo when compared to the ADR group (Fig.l8). Retinoic acid (l pM) administration
caused 50 o/o increase in the total RAR receptor levels when compared to control but the
change was not statistically signifrcant (Fig. 16). The same treatment resulted inthe 97o/o
increase in the totat RXR receptor levels (Fig. 17). The changes in combined RAR and
RXR receptor levels resulted in the 42 % decrease in the RARIRXR receptor ratio when
compared to the control (Fig. 18).
96