il\VOLVEMENT OF RETII\OIC ACID II{ - MSpace at the University of ...

significantly decreased when compared to both ADR and CONT gloups (Fig.18). The
treatment with I pM retinoic acid resulted in a 65Yo increase in the total RAR receptor
levels when compared to the ADR goup. The total RXR receptor levels in this goup
were found to be unchanged when compared to the CONT group. The RARIRXR ratio
was increased by 65Yo as compared to the CONT group.
ILu2. 9uM Adtiamvcin TreaÍment
Adriamycin (B pM) caused a 50Yo decrease in the total RAR and no change in the
RXR receptor levels when compared to the CONT group (Fig. 16 and 17). The changes
v,'ere accompanied by a 45Yo decrease in the RAR/RXR ratio (Fig. 18). In the presence of
trolo:i; the depressive effect of adriamycin on the total RAR was diminished and there
was no change in RXR. This resulted in significant depression of RAR/RXR receptor
ratio when compared to ADR and this ratio was still depressed when compared to CONT.
Retinoic acid (0.1 t¡vt¡ and adriamycin (8 ¡rM) caused a significant decrease in the total
RAR and no change in the RXR receptor levels (Fig 16 and 17) while the ratio of
RAR/RXR was less than44Yo of CONT. (Fig 18). Treatment with 1 UM retinoic acid
and adriamycin increased both the total RAR and RJ(R receptor levels to over 200% (Fig.
16 and 17). The ratio of RARIRXR in this goup was significantly increased (I75%)
when compared to ADR @ig 18)
II.aS. 70 uM Adríømvcin Treafment
The administration of 10 ¡rM of adriamycin to the ADR group myocytes resulted
in2IYo decrease in the total RAR and caused no change in the RXR receptor levels @ig.
16 and 17) leading to a l08Yo increase in the RAR/RXR receptor ratio when compared to
CONT goup (Fig. 18). The administration of trolox to 10 ¡rM adriamycin treated cells