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Our sense organs 45

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One cell contains 32 pg (1 picogram = 10 -12 g)<br />

hemoglobin, comprising about 300 million molecules.<br />

This red pigment comprises about 95 % of<br />

the dry weight of erythrocytes. Interestingly, the<br />

32 pg per cell in an adult organism is practically<br />

a universal constant for the animal kingdom.<br />

In terms of volume the quantity of Hb is about<br />

140 g/l for adult women, and 160 g/l for men.<br />

Consisting of four pyrrole rings connected by<br />

methine bridges ( – CH = ), the heme has a bivalent<br />

iron atom at its centre. Oxygen can be<br />

attached to the central iron atom without<br />

changing its chemical valence. The Creator<br />

designed this amazing structure without which<br />

human life would not have been possible. Consider<br />

the following:<br />

Eosinophilic granulocyte Platelets (thrombocytes) Small lymphocyte<br />

The body thus has a total quantity of between<br />

700 and 960 grams of Hb available in its 5 to<br />

6 litres of blood. The percentage of iron in hemoglobin<br />

is 0.334 %, so that 3 grams, or 70 %, of all<br />

the iron in the body is located in the hemoglobin.<br />

Each of these Hb molecules is a complex protein,<br />

consisting of globin (Greek globus = sphere)<br />

which is connected to an iron-containing pigment<br />

component, heme (Greek haima = blood) by<br />

means of four polypeptide chains. Because of the<br />

four chains this protein is known as a tetrameric<br />

protein (Greek tetra = four). Two of these chains<br />

consist of 141 amino acids (the α chain ), and the<br />

other two have 146 amino acids (the β chain).<br />

The normal hemoglobin for an adult is indicated<br />

by Hb-α 2 β 2 or simply HbA. The exact sequence of<br />

the amino acids in the chains is of crucial importance<br />

for the structure of the globin molecule.<br />

Small deviations can seriously affect its function.<br />

60<br />

Normally, in the presence of water and oxygen,<br />

the iron in free heme is immediately oxidised to<br />

tri-valent iron (hematin); it cannot then absorb<br />

any oxygen. The Creator prevented this futile reaction<br />

by shaping the globin chain to form a protective<br />

coat. This chain also has other important<br />

functional properties:<br />

In the first place the absorption of oxygen is reversible,<br />

since it does not depend on a chemical<br />

bond. If a chemical bond had to be severed, energy<br />

would have been required. Secondly, the<br />

quantity of oxygen to be absorbed or released<br />

can be regulated, making it possible to supply<br />

varying levels of oxygen to peripheral <strong>organs</strong><br />

according to their physiological requirements.<br />

It can also be stated thus: Human life could not<br />

have existed without the finely tuned properties<br />

of hemoglobin, which are the result of its well<br />

designed molecular structure.

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