Motor proteins, cellular motility Regulation of actin treadmilling

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04/10/2013 S1 head tilting model Huxley AF, Simmons RM. Proposed mechanism of force generation in striated muscle. Nature. 1971 Oct 22;233(5321):533-8 The swinging lever arm model • Rigor-dissociation step: ATP binding → dissociation form the actin filament • Priming (back swing) of the lever arm • ATP hydrolysis: reattachment • Power stroke: force generating swing of the lever arm MECHANOCHEMICAL COUPLING! Kühner S, Fischer S. Structural mechanism of the ATP-induced dissociation of rigor myosin from actin. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7793-8. 6
04/10/2013 • 1985: Ron Vale • XIV kinesin families • microtubule based motor proteins • They move towards the plus end of MT • Functions: − organelle movement − Assembly of cilia and flagella − − Kinesins Signaling pathways Mitotic spindle formation and transportation of the chromosomes • The end! 7
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Motor proteins, cellular motility Regulation of actin treadmilling

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