Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
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04/10/2013<br />
S1 head tilting model<br />
Huxley AF, Simmons RM. Proposed mechanism <strong>of</strong> force generation in striated muscle. Nature. 1971 Oct 22;233(5321):533-8<br />
The swinging lever arm model<br />
• Rigor-dissociation step: ATP binding → dissociation form the <strong>actin</strong> filament<br />
• Priming (back swing) <strong>of</strong> the lever arm<br />
• ATP hydrolysis: reattachment<br />
• Power stroke: force generating swing <strong>of</strong> the lever arm<br />
MECHANOCHEMICAL COUPLING!<br />
Kühner S, Fischer S. Structural mechanism <strong>of</strong> the ATP-induced dissociation <strong>of</strong> rigor myosin from <strong>actin</strong>. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7793-8.<br />
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