Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
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04/10/2013<br />
Directionality<br />
• Track polarity: + and – ends <strong>of</strong> the <strong>actin</strong> filaments and the<br />
microtubules<br />
• <strong>Motor</strong>s move unidirectionally<br />
−<br />
−<br />
−<br />
myosin: toward the + end <strong>of</strong> micr<strong>of</strong>ilaments<br />
kinesin: toward the + end <strong>of</strong> microtubules<br />
dynein: toward the – end <strong>of</strong> microtubules<br />
Myosins<br />
• Actin-based motors<br />
• conventional myosins (myosin II – 1864: Wilhelm Kühne)<br />
• nonconventional myosins<br />
• Myosin families: myosin I-XVIII<br />
• Functions:<br />
− muscle contraction<br />
− cytokinesis<br />
4