Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
Motor proteins, cellular motility Regulation of actin treadmilling
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04/10/2013<br />
Basic components <strong>of</strong> the<br />
cytoskeletal transport system<br />
• <strong>Motor</strong><br />
− Myosin, kinesin, dynein<br />
• Track<br />
− Micr<strong>of</strong>ilaments, microtubules<br />
• Cargo<br />
− organelles, chromosomes, vesicles<br />
• Fuel<br />
− ATP, GTP<br />
Common properties<br />
Structure<br />
• N-terminal globular head:<br />
motor domain<br />
− nucleotide binding and hydrolysis<br />
− specific binding sites for the corresponding filaments<br />
• C-terminal: structural and functional role with specificity<br />
N<br />
C<br />
Mechanical properties, function<br />
In principle: cyclic function and work<br />
<strong>Motor</strong> → binding to a filament → force → dissociation → relaxation<br />
1 cycle requires 1 ATP hydrolysis<br />
They can either move or produce force<br />
3