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Japan Marine Science and Technology Center Frontier Research System for Extremophiles Activities of Bio-Venture Center for Extremophiles 1. The second Bio-Venture forum The forum was held at Yokosuka headquarters of JAMSTEC to introduce the achievements of the Frontier Research System for Extremophiles in the form of lectures to companies and look for opportunities of collaboration with them. The forum attracted more than participants from biotechnology companies. The participants exchanged interesting ideas at the forum. Program of the forum: Organizer: Japan Marine Science and Technology Center Frontier Research System for Extremophiles Bio-Venture Center for Extremophiles Time: :-:, Friday, November , . Place: The main conference room, the first floor of the main building, JAMSTEC, Yokosuka Headquarters. Program: : Purposes and the importance of Bio-Venture Center for Extremophiles Executive Managing Director, M. Chijiya : Rules and operations of the Bio-Venture Center Head of Frontier Research Promotion Department, K. Takahashi : Scientific activities of the Frontier Research System for Extremophiles Director General, Prof. K. Horikoshi : Searching for genetic potentials from genomes of deep-sea Bacillus Researcher, Dr. Y. Takaki :–: Lunch : Tour in JAMSTEC (Show room, Deep-sea exploration diving [Shinkai ], Supporting mother ship [Yokosuka], Facilities and equipments for studying deep-sea microorganisms) : Screening for useful microorganisms and hot-vector system for hyper-expression Researcher, Dr. Y. Hatada : Break : Special lecture (Jurisdiction of government-independent Institutions and industry-university cooperation) The Rector of Tokyo Institute of Technology, Prof. M. Aizawa : Diversity of deep sea bacteria and preservation of useful strains Researcher, Dr. Y. Nogi : Development of the method for culture tissue of deep-sea animals under high-pressure conditions Researcher, Dr. J. Koyama : Banquet 85
JAMSTEC 2002 Annual Report Frontier Research System for Extremophiles 2. Studies on applications of microorganisms To have effective collaboration researches with companies our frontier researches are focused on finding out the seeds of attractive applications. To achieve this goal, studies on functionality of genes, substances, proteins, and useful enzymes from the deep sea, earth's crust, and special environments are the first step. Further characterization and finding applications of the above will be done as the next steps. So far, we have discovered highly alkaline α-amylases, highly alkaline CGTases, new mannanases, a super-alkaline protease, new agarases, and useful enzymes from genome sequences. Analyzing and genetic engineering of a high alkaline proteases, development of enzymes using for production of oligo-saccharides, post-genome studies of Bacillus halodurans (pH adaptation), and crystallization of useful enzymes are also in progress. 3. Collaboration researches with companies Currently, collaboration with companies, including pharmaceutical, food, chemical, computer soft, and off-scouring treatment companies, have resulted in the dispatch of researchers to our center for joint research. 86
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