Coagulation Made Simple

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Receptor Exposure, Activation ADP PDGF 5-HT Granule Release Platelets Adherence vWF GPIb Activation Collagen Thrombin ADP Epi TxA2 Thromboxane A2 Bind Clotting Factors Fibrinogen Aggregation GPIIb GPIIIa Vasoconstriction Platelet Plug (Surface) PL Thrombosis
<strong>Coagulation</strong> Factors • I Fibrinogen • II Prothrombin • III Thromboplastin • IV Calcium • V Proaccelerin • VI Same as V • VII Proconvertin • VIII Antihemophilic • IX • X • XI • XII Christmas Stuart-Prower Plasma thromboplastin antecedent Hageman • XIII Fibrin stabilizing
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5: Vascular Injury Vasoconstriction Fi
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19 and 20: Acquired or Inherited Factor Disord
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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