Coagulation Made Simple

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Life saver? rFVIIa • Recombinant (activated) Factor VII – Initiates hemostasis at sites of bleeding • Directly activates thrombin on platelets – Used in various complex settings • Hemophilia, inhibitors to factors VIII or IX • Warfarin-associated bleeding • Massive transfusion coagulopathy • Acute intracerebral hemorrhage • Cardiac Surgery • Severe trauma
FVIIa • Anticoagulant reversal agent? – Hemorrhage due to LMWH – anecdotal – Potential reversal agent for most of the newer anticoagulant agents? • Reports of efficacy are derived from lab experiments or from healthy volunteers – Reversal of warfarin – Reversal of hirudin – Reversal of fondaparinux • Recommendations will require clinical data
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19 and 20: Acquired or Inherited Factor Disord
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 37 and 38: Evaluation of Excessive Intraoperat
Page 39: Evaluation of Excessive Intraoperat
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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