Coagulation Made Simple

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Evaluation of Excessive Intraoperative or Postoperative Bleeding • Previously undetected hemostatic defect – Congenital defects • Factor deficiencies – VIII (Hemophilia A, and/or von Willebrand’s disease) – IX (Hemophilia B or Christmas disease) – XI (Hemophilia C) – II, V, and X – VII – XIII – Transfusion purpura • Antibodies to donor platelets, which eventually destroy the host’s own platelets
Evaluation of Excessive Intraoperative or Postoperative Bleeding • Consumptive coagulopathy (DIC) vs Fibrinolysis – No single test can confirm or exclude the diagnosis or distinguish between the two • Thrombocytopenia, positive plasma protamine test for fibrin monomers, a low fibrinogen level (
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19 and 20: Acquired or Inherited Factor Disord
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 37: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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