Coagulation Made Simple
Coagulation Made Simple
Coagulation Made Simple
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Laboratory Monitoring of <strong>Coagulation</strong><br />
• Four causes of elevated aPTT and response to 50:50 mix<br />
o Factor XI, IX, or VIII deficiency<br />
o Corrects with 50:50 mix (normal pool plasma)<br />
o Factor XI, IX, or VIII specific factor inhibitor<br />
o May correct at time zero but then prolongs<br />
o Heparin contamination<br />
o Does not correct at all with normal pool plasma<br />
o Antiphospholipid antibodies<br />
o Does not fully correct at time zero or any time point
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