Coagulation Made Simple

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Laboratory Monitoring of <strong>Coagulation</strong> • Activated Partial Thromboplastin Time (aPTT) – Plasma + Calcium + Kaolin + Phospholipids Contact → XIa → IXa + VIII →Xa + Va →IIa →CLOT • PTT only elevated • Factor XI, IX, or VIII deficiency • Factor XI, IX, or VIII specific factor inhibitor • Heparin contamination • Antiphospholipid antibodies
Laboratory Monitoring of <strong>Coagulation</strong> • Both PT-INR and aPTT are elevated – Factor(s) X, V, or II deficiency – Factor(s) X, V, or II inhibitor – Improper anticoagulation ratio (Hct >60 or ↑ PT-INR) – Large Warfarin effect ((↑ PT-INR > ↑ aPTT) – Low fibrinogen (
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19 and 20: Acquired or Inherited Factor Disord
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27: Laboratory Monitoring of Coagulatio
Page 31 and 32: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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