Coagulation Made Simple
Coagulation Made Simple
Coagulation Made Simple
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Laboratory Monitoring of <strong>Coagulation</strong><br />
• Prothrombin Time (PT-INR)<br />
– Plasma + Calcium + Tissue Thromboplastin<br />
TF + VIIa → Xa + V → IIa → CLOT<br />
• PT-INR only elevated<br />
– Factor VII deficiency<br />
• Congenital (very rare)<br />
• Acquired (Vit K deficiency, liver disease)<br />
– Factor VII inhibitor<br />
– Rarely in pts with modest decreases of factor V or X
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