Coagulation Made Simple

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Will my patient bleed? • Level III concern – History is suggestive of poor hemostasis – Procedure may impair hemostasis (CPB or cell saver) or the procedure may leave behind a large, raw surface – Minimal post-operative bleeding will be injurious (craniotomy) Platelet count, PT-INR, aPTT, +/- bleeding time (PFA-100)
Will my patient bleed? • Level IV concern – History highly suggestive of a hemostatic defect – Hematology consult Platelet count, bleeding time, PT-INR, aPTT, euglobulin clot lysis analysis, factor assays Bleeding time test + ASA provocative test If emergent – platelet aggregation testing and thrombin time (TEG, if available)
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19 and 20: Acquired or Inherited Factor Disord
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23: Will my patient bleed? • Level II
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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