Coagulation Made Simple

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Von Willebrand Disease (vWD) • The most common inherited bleeding disorder – 1% of the population – Five forms or types are known and distinguishable – Classic – reduced VIII activity and decreased vWF • vWF is crucial for the interaction of platelets with damaged vasculature • vWF is also the carrier protein for factor VIII (otherwise, free VIII is labile in the plasma) • vWD usually results from either a drop in vWF concentration or impaired vWF/VIII function
Von Willebrand Disease (vWD) • Patients with vWD have “platelet-type” bleeding (nosebleeds and bruising) – Joint bleeding is rare – Bleeding as a child, less as an adult – Testing (a challenge) • Bleeding time (variable sensitivity) • Factor VIII level • Von Willebrand antigen • Ristocetin cofactor activity (binds vWF to platelets) • Crossed immunoelectrophoresis • Therapy: DDAVP, Humate-P, cryoprecipitate
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17 and 18: Inherited Defects of Platelet Funct
Page 19: Acquired or Inherited Factor Disord
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

Coagulation Made Simple

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