Coagulation Made Simple

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Acquired or Inherited Factor Disorder? • Acquired bleeding factor disorders will often present suddenly with severe bleeding and newly abnormal coagulation tests – Patients have other illnesses but autoimmune coagulation disorders can suddenly strike any previously healthy person
Acquired or Inherited Factor Disorder? • Inherited bleeding factor disorders – Present from birth until old age – Mild hemophilia or von Willebrand disease patients may not have had troublesome bleeding until the first trauma or surgery • Do not ignore an abnormal aPTT in an older patient • Review family history – Hemophilia A/B are sex-linked - brothers, cousins, uncles – Von Willebrand disease may have variable penetrance within the family
Page 1 and 2: Coagulation Made Simple Thomas A. W
Page 3 and 4: Black Box View of Hemostasis Platel
Page 5 and 6: Vascular Injury Vasoconstriction Fi
Page 7 and 8: Coagulation Factors • I Fibrinoge
Page 9 and 10: “Classic” (Test Tube) Coagulati
Page 11 and 12: Factor VII - Tissue Factor “two-u
Page 13 and 14: Physiologic Anticoagulant Mechanism
Page 15 and 16: Will my patient bleed? • “Are y
Page 17: Inherited Defects of Platelet Funct
Page 21 and 22: Von Willebrand Disease (vWD) • Pa
Page 23 and 24: Will my patient bleed? • Level II
Page 25 and 26: Will my patient bleed? • Level IV
Page 27 and 28: Laboratory Monitoring of Coagulatio
Page 33 and 34: HEROIC AWARD TIME!! Save of the Mon
Page 35 and 36: Evaluation of Excessive Intraoperat
Page 41 and 42: FVIIa • Anticoagulant reversal ag
Page 43 and 44: Heparin- Induced Thrombocytopenia
Page 45 and 46: Anticoagulants Approved for Use by
Page 47: Black Box View of Hemostasis Platel

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