Types of mutations and their impact on protein function Today's ...
Types of mutations and their impact on protein function Today's ...
Types of mutations and their impact on protein function Today's ...
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From my Lecture 4 (10/1):<br />
Classificati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>mutati<strong>on</strong>s</str<strong>on</strong>g> by <str<strong>on</strong>g>their</str<strong>on</strong>g><br />
effects <strong>on</strong> the DNA molecule<br />
• Substituti<strong>on</strong>: base is replaced by <strong>on</strong>e <str<strong>on</strong>g>of</str<strong>on</strong>g> the other<br />
three bases<br />
• Deleti<strong>on</strong>: block <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>on</strong>e or more DNA pairs is lost<br />
• Inserti<strong>on</strong>: block <str<strong>on</strong>g>of</str<strong>on</strong>g> <strong>on</strong>e or more DNA pairs is added<br />
• Inversi<strong>on</strong>: 180˚ rotati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> piece <str<strong>on</strong>g>of</str<strong>on</strong>g> DNA<br />
• Reciprocal translocati<strong>on</strong>: parts <str<strong>on</strong>g>of</str<strong>on</strong>g> n<strong>on</strong>homologous<br />
chromosomes change places<br />
• Chromosomal rearrangements: affect many genes at<br />
<strong>on</strong>e time<br />
2
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