DIRECT COMPRESSION
DIRECT COMPRESSION
DIRECT COMPRESSION
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<strong>DIRECT</strong> <strong>COMPRESSION</strong><br />
Manufacturing Flowchart [I]<br />
LACTOSE<br />
Active<br />
Material<br />
MICROCRYSTALLINE<br />
CELLULOSE<br />
SUPER<br />
DISINTEGRANTS<br />
Development<br />
Content Uniformity on<br />
unlubricated blend to<br />
establish mixing time<br />
AQUEOUS<br />
FILM COAT<br />
To printing<br />
SDL(30%) - MCC(60%)<br />
Roller mixer<br />
MIX Y-cone<br />
Mill<br />
Where necessary<br />
0.6 -0.8 mm<br />
MIX Y-cone<br />
BLEND STEP<br />
rpm + time<br />
COMPRESS<br />
FLUSH<br />
COATED DC TABLETS<br />
SUITABILITY:<br />
Glibenclamide 5 mg<br />
Selegiline 5 mg<br />
Famotidine 10/20/40 mg<br />
Bromhexine 8 mg<br />
Amitriphyline 10 mg<br />
Lubricant<br />
and Glidant<br />
SIEVE<br />
50 MESH<br />
MIX<br />
rpm + time<br />
IPQC<br />
ID<br />
Assay<br />
Content Uniformity<br />
QC<br />
Weight uniformity<br />
Thickness<br />
Hardness<br />
Disintegration<br />
RELEASE<br />
ID<br />
Assay<br />
Content Uniformity<br />
Dissolution<br />
Lubricant coats<br />
the lactose<br />
providing<br />
greater control<br />
over final<br />
blending stage
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