Acros Organics & Maybridge - D
Acros Organics & Maybridge - D
Acros Organics & Maybridge - D
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D<br />
Diisopropyla http://www.maybridge.com<br />
Diisopropyl azodicarboxylate<br />
APPLICATION GUIDE<br />
Deprotecting Group Chemistry<br />
* Deprotection of Bz group Selective N-debenzylation of benzylamino derivatives of 1,6-anhydro--Dhexopyranoses.<br />
OL 2000, 2, 1681<br />
Mitsunobu Chemistry<br />
* Amine to isocyanate Primary amines with triphenylphosphine, with dialkyanilines with<br />
tributylphosphine. TL 1999, 40, 363<br />
* Aziridination Synthesis of N-H vinylaziridines. T 2002, 58, 5979<br />
* Coupling of alcohols to acids Alternative to DEAD, more stable at high temperatures. S 1981, 3<br />
* Coupling of alcohols to amines Alternative to DEAD, more stable at high temperatures. S 1981, 1<br />
* Coupling of alcohols to imides Alternative to DEAD, more stable at high temperatures. S 1981, 2<br />
Diisopropyl azodicarboxylate, 94%<br />
<strong>Acros</strong> <strong>Organics</strong> Product code Packaging Pack size Price<br />
327560050 Glass bottle 5 g INR 680<br />
327560250 Glass bottle 25 g INR 910<br />
327561000 Glass bottle 100 g INR 2,240<br />
R36/37/38 R51/53<br />
S26 S29 S36/37/39<br />
S61<br />
Light sensitive<br />
Heat sensitive<br />
Store below +4ºC<br />
C8H14N2O4 CAS: 2446-83-5<br />
MFCD00008875<br />
FW: 202.21<br />
Diisopropylbenzene, 98%<br />
2:1 mixture of m- and p-isomer<br />
(CH 3 ) 2 CHO 2 CN=NCO 2 CH(CH 3 ) 2<br />
mp: 3-5 °C<br />
bp: 75 °C (0.2 mmHg)<br />
Fp: 106 °C<br />
d: 1.020<br />
n 20<br />
D : 1.418 -1.422<br />
<strong>Acros</strong> <strong>Organics</strong> Product code Packaging Pack size Price<br />
407810010 Glass bottle 1 kg INR 3,680<br />
407810030 Plastic drum 3 kg INR 8,240<br />
S24/25 C 12 H 18 ((CH 3 ) 2 CH) 2 C 6 H 4<br />
CAS: 25321-09-9<br />
MFCD00054263<br />
FW: 162.27<br />
1,4-Diisopropylbenzene, 99%<br />
bp: 77-82 °C (10 mm<br />
Hg)<br />
Fp: 71 °C<br />
d: 0.850<br />
n 20<br />
D : 1.488 -1.491<br />
<strong>Acros</strong> <strong>Organics</strong> Product code Packaging Pack size Price<br />
155210050 Glass bottle 5 g INR 590<br />
155210250 Glass bottle 25 g INR 1,290<br />
155211000 Glass bottle 100 g INR 3,700<br />
S24/25 C 12 H 18 C 6 H 4 [CH(CH 3 ) 2 ] 2<br />
CAS: 100-18-5<br />
MFCD00008892<br />
FW: 162.27<br />
mp: -17 °C<br />
bp: 203 °C<br />
Fp: 76 °C<br />
d: 0.850<br />
n 20<br />
D : 1.489 -1.491<br />
N,N'-Diisopropylcarbodiimide<br />
APPLICATION GUIDE<br />
Interconversion of functional groups<br />
* Carboxylic acid to anhydride Coupling agent used in peptide synthesis. TL 1994, 35, 5981<br />
* Carboxylic acid to ester Carbodiimide coupling agent. TL 1994, 35, 5981<br />
832 Please enquire for bulk quantities<br />
N,N'-Diisopropylcarbodiimide, 99%<br />
<strong>Acros</strong> <strong>Organics</strong> Product code Packaging Pack size Price<br />
115210050 Glass bottle 5 g INR 710<br />
115210250 Glass bottle 25 g INR 1,820<br />
115211000 Glass bottle 100 g INR 4,190<br />
115215000 Glass bottle 500 g INR 16,560<br />
R10 R26 R36/37/38<br />
R41 R42/43<br />
S16 S26 S28A S38<br />
S45<br />
Moisture sensitive<br />
C7H14N2 CAS: 693-13-0<br />
MFCD00065689<br />
FW: 126.20<br />
Diisopropyl ether , see Isopropyl ether on page 1263<br />
(CH 3 ) 2 CHN=C=NCH(CH 3 ) 2<br />
bp: 145-148 °C<br />
Fp: 33 °C<br />
d: 0.810<br />
Diisopropyl cyanomethylphosphonate, 97%<br />
n 20<br />
D : 1.432 -1.435<br />
<strong>Acros</strong> <strong>Organics</strong> Product code Packaging Pack size Price<br />
224260050 Glass bottle 5 g INR 2,190<br />
R20/21/22 R36/37/<br />
38 R32<br />
S26 S36/37/39 S50A<br />
C8H16NO3P CAS: 58264-04-3<br />
MFCD00009812<br />
FW: 205.20<br />
bp: 108-110 °C<br />
Fp: 110 °C<br />
d: 1.030<br />
n 20<br />
D : 1.428 -1.43<br />
N,N-Diisopropylethylamine<br />
APPLICATION GUIDE<br />
Acylation<br />
* Base Bodanszky, M.; Bodanszky, A. The Practice of Peptide Synthesis Springe r: Berlin, 1984<br />
* Peptide coupling For coupling of N-methyl amino acids. TL 1991, 32, 1967<br />
Alkylation<br />
Hindered base, non-nucleophilic. JOC 1993, 58, 1604<br />
* Alkyl sulfination JOC 1992, 57, 6789<br />
* N-Alkylation CL 1988, 1381<br />
* O-Alkylation Methylation of phenols and enols. CPB 1984, 32, 3759<br />
Asymmetric synthesis<br />
* Asymmetric Heck Reaction CRV 1989, 89, 1433<br />
Carbonylation<br />
* Allyl phosphates to a,b-unsaturated esters JOC 1993, 58, 1538<br />
Condensation Reactions<br />
* Aldol condensation Top. Stereochem. 1982, 13, 1<br />
Ether formation<br />
* From an unsaturated alcohol From phenylsulfenyl chloride and an unsaturated alcohol. JOC 1993,<br />
58, 1450<br />
Interconversion of functional groups<br />
* Carboxylic acid to ester Esterification of hindered carboxylic acids. TL 1971, 4741<br />
Lactonisation, lactamisation<br />
* From an unsaturated carboxylic acid From phenylsulfenyl chloride and an unsaturated carboxylic<br />
acid. JOC 1993, 58, 1449<br />
Organic Base<br />
* Alcohol protection Greene, T W.; Wuts P. G. M. Protective Groups In Organic Synthesis Wil ey: New<br />
York, 1991.<br />
* Aldol condensation Top. Stereochem. 1982, 13, 1<br />
* Alkylation Hindered base, non-nucleophilic. JOC 1993, 58, 1604<br />
* Enolate generation of esters JACS 1991, 113, 4026<br />
* Enolate generation of ketones JOC 1992, 57, 499, 2716<br />
* For peptide couplings Bodanszky, M.; Bodanszky, A. The Practice of Peptide Synthesis Springe r:<br />
Berlin, 1984<br />
Protecting Group Chemistry<br />
* Protection of alcohols Greene, T W.; Wuts P. G. M. Protective Groups In Organic Synthesis Wil ey:<br />
New York, 1991.<br />
Reduction<br />
* Deoxygenation Deoxygenation of acetals to enol ethers. TL 1985, 26, 5303<br />
N<br />
O<br />
O<br />
P<br />
O
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